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Efficacy versus abundancy: Comparing vaccination schemes

We introduce a novel compartmental model accounting for the effects of vaccine efficacy, deployment rates and timing of initiation of deployment. We simulate different scenarios and initial conditions, and we find that higher abundancy and rate of deployment of low efficacy vaccines lowers the cumul...

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Detalles Bibliográficos
Autores principales: El Deeb, Omar, Jalloul, Maya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097986/
https://www.ncbi.nlm.nih.gov/pubmed/35552553
http://dx.doi.org/10.1371/journal.pone.0267840
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author El Deeb, Omar
Jalloul, Maya
author_facet El Deeb, Omar
Jalloul, Maya
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description We introduce a novel compartmental model accounting for the effects of vaccine efficacy, deployment rates and timing of initiation of deployment. We simulate different scenarios and initial conditions, and we find that higher abundancy and rate of deployment of low efficacy vaccines lowers the cumulative number of deaths in comparison to slower deployment of high efficacy vaccines. We also forecast that, at the same daily deployment rate, the earlier introduction of vaccination schemes with lower efficacy would also lower the number of deaths with respect to a delayed introduction of high efficacy vaccines, which can however, still achieve lower numbers of infections and better herd immunity.
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spelling pubmed-90979862022-05-13 Efficacy versus abundancy: Comparing vaccination schemes El Deeb, Omar Jalloul, Maya PLoS One Research Article We introduce a novel compartmental model accounting for the effects of vaccine efficacy, deployment rates and timing of initiation of deployment. We simulate different scenarios and initial conditions, and we find that higher abundancy and rate of deployment of low efficacy vaccines lowers the cumulative number of deaths in comparison to slower deployment of high efficacy vaccines. We also forecast that, at the same daily deployment rate, the earlier introduction of vaccination schemes with lower efficacy would also lower the number of deaths with respect to a delayed introduction of high efficacy vaccines, which can however, still achieve lower numbers of infections and better herd immunity. Public Library of Science 2022-05-12 /pmc/articles/PMC9097986/ /pubmed/35552553 http://dx.doi.org/10.1371/journal.pone.0267840 Text en https://creativecommons.org/publicdomain/zero/1.0/This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 (https://creativecommons.org/publicdomain/zero/1.0/) public domain dedication.
spellingShingle Research Article
El Deeb, Omar
Jalloul, Maya
Efficacy versus abundancy: Comparing vaccination schemes
title Efficacy versus abundancy: Comparing vaccination schemes
title_full Efficacy versus abundancy: Comparing vaccination schemes
title_fullStr Efficacy versus abundancy: Comparing vaccination schemes
title_full_unstemmed Efficacy versus abundancy: Comparing vaccination schemes
title_short Efficacy versus abundancy: Comparing vaccination schemes
title_sort efficacy versus abundancy: comparing vaccination schemes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097986/
https://www.ncbi.nlm.nih.gov/pubmed/35552553
http://dx.doi.org/10.1371/journal.pone.0267840
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