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Sensitivity to gait improvement after levodopa intake in Parkinson’s disease: A comparison study among synthetic kinematic indices

The synthetic indices are widely used to describe balance and stability during gait. Some of these are employed to describe the gait features in Parkinson’s disease (PD). However, the results are sometimes inconsistent, and the same indices are rarely used to compare the individuals affected by PD b...

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Autores principales: Troisi Lopez, Emahnuel, Minino, Roberta, Sorrentino, Pierpaolo, Manzo, Valentino, Tafuri, Domenico, Sorrentino, Giuseppe, Liparoti, Marianna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098031/
https://www.ncbi.nlm.nih.gov/pubmed/35551300
http://dx.doi.org/10.1371/journal.pone.0268392
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author Troisi Lopez, Emahnuel
Minino, Roberta
Sorrentino, Pierpaolo
Manzo, Valentino
Tafuri, Domenico
Sorrentino, Giuseppe
Liparoti, Marianna
author_facet Troisi Lopez, Emahnuel
Minino, Roberta
Sorrentino, Pierpaolo
Manzo, Valentino
Tafuri, Domenico
Sorrentino, Giuseppe
Liparoti, Marianna
author_sort Troisi Lopez, Emahnuel
collection PubMed
description The synthetic indices are widely used to describe balance and stability during gait. Some of these are employed to describe the gait features in Parkinson’s disease (PD). However, the results are sometimes inconsistent, and the same indices are rarely used to compare the individuals affected by PD before and after levodopa intake (OFF and ON condition, respectively). Our aim was to investigate which synthetic measure among Harmonic Ratio, Jerk Ratio, Golden Ratio and Trunk Displacement Index is representative of gait stability and harmony, and which of these are more sensitive to the variations between OFF and ON condition. We found that all indices, except the Jerk Ratio, significantly improve after levodopa. Only the improvement of the Trunk Displacement Index showed a direct correlation with the motor improvement measured through the clinical scale UPDRS-III (Unified Parkinson’s Disease Rating Scale–part III). In conclusion, we suggest that the synthetic indices can be useful to detect motor changes induced by, but not all of them clearly correlate with the clinical changes achieved with the levodopa administration. In our analysis, only the Trunk Displacement Index was able to show a clear relationship with the PD clinical motor improvement.
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spelling pubmed-90980312022-05-13 Sensitivity to gait improvement after levodopa intake in Parkinson’s disease: A comparison study among synthetic kinematic indices Troisi Lopez, Emahnuel Minino, Roberta Sorrentino, Pierpaolo Manzo, Valentino Tafuri, Domenico Sorrentino, Giuseppe Liparoti, Marianna PLoS One Research Article The synthetic indices are widely used to describe balance and stability during gait. Some of these are employed to describe the gait features in Parkinson’s disease (PD). However, the results are sometimes inconsistent, and the same indices are rarely used to compare the individuals affected by PD before and after levodopa intake (OFF and ON condition, respectively). Our aim was to investigate which synthetic measure among Harmonic Ratio, Jerk Ratio, Golden Ratio and Trunk Displacement Index is representative of gait stability and harmony, and which of these are more sensitive to the variations between OFF and ON condition. We found that all indices, except the Jerk Ratio, significantly improve after levodopa. Only the improvement of the Trunk Displacement Index showed a direct correlation with the motor improvement measured through the clinical scale UPDRS-III (Unified Parkinson’s Disease Rating Scale–part III). In conclusion, we suggest that the synthetic indices can be useful to detect motor changes induced by, but not all of them clearly correlate with the clinical changes achieved with the levodopa administration. In our analysis, only the Trunk Displacement Index was able to show a clear relationship with the PD clinical motor improvement. Public Library of Science 2022-05-12 /pmc/articles/PMC9098031/ /pubmed/35551300 http://dx.doi.org/10.1371/journal.pone.0268392 Text en © 2022 Troisi Lopez et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Troisi Lopez, Emahnuel
Minino, Roberta
Sorrentino, Pierpaolo
Manzo, Valentino
Tafuri, Domenico
Sorrentino, Giuseppe
Liparoti, Marianna
Sensitivity to gait improvement after levodopa intake in Parkinson’s disease: A comparison study among synthetic kinematic indices
title Sensitivity to gait improvement after levodopa intake in Parkinson’s disease: A comparison study among synthetic kinematic indices
title_full Sensitivity to gait improvement after levodopa intake in Parkinson’s disease: A comparison study among synthetic kinematic indices
title_fullStr Sensitivity to gait improvement after levodopa intake in Parkinson’s disease: A comparison study among synthetic kinematic indices
title_full_unstemmed Sensitivity to gait improvement after levodopa intake in Parkinson’s disease: A comparison study among synthetic kinematic indices
title_short Sensitivity to gait improvement after levodopa intake in Parkinson’s disease: A comparison study among synthetic kinematic indices
title_sort sensitivity to gait improvement after levodopa intake in parkinson’s disease: a comparison study among synthetic kinematic indices
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098031/
https://www.ncbi.nlm.nih.gov/pubmed/35551300
http://dx.doi.org/10.1371/journal.pone.0268392
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