Cargando…

Heat shock induces premature transcript termination and reconfigures the human transcriptome

The heat shock (HS) response involves rapid induction of HS genes, whereas transcriptional repression is established more slowly at most other genes. Previous data suggested that such repression results from inhibition of RNA polymerase II (RNAPII) pause release, but here, we show that HS strongly a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cugusi, Simona, Mitter, Richard, Kelly, Gavin P., Walker, Jane, Han, Zhong, Pisano, Paola, Wierer, Michael, Stewart, Aengus, Svejstrup, Jesper Q.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098121/ https://www.ncbi.nlm.nih.gov/pubmed/35114099 http://dx.doi.org/10.1016/j.molcel.2022.01.007

Ejemplares similares

SCAF4 and SCAF8, mRNA Anti-Terminator Proteins
por: Gregersen, Lea H., et al.
Publicado: (2019)

RECQL5 Controls Transcript Elongation and Suppresses Genome Instability Associated with Transcription Stress
por: Saponaro, Marco, et al.
Publicado: (2014)

UV Irradiation Induces a Non-coding RNA that Functionally Opposes the Protein Encoded by the Same Gene
por: Williamson, Laura, et al.
Publicado: (2017)

Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability
por: Zatreanu, Diana, et al.
Publicado: (2019)

Mutation of cancer driver MLL2 results in transcription stress and genome instability
por: Kantidakis, Theodoros, et al.
Publicado: (2016)

Translation stress and collided ribosomes are co-activators of cGAS
por: Wan, Li, et al.
Publicado: (2021)

Elongation factor-specific capture of RNA polymerase II complexes
por: Gregersen, Lea H., et al.
Publicado: (2022)

Pharmacological Bypass of Cockayne Syndrome B Function in Neuronal Differentiation
por: Wang, Yuming, et al.
Publicado: (2016)

A ubiquitylation site in Cockayne syndrome B required for repair of oxidative DNA damage, but not for transcription-coupled nucleotide excision repair
por: Ranes, Michael, et al.
Publicado: (2016)

Evidence That STK19 Is Not an NRAS-dependent Melanoma Driver
por: Rodríguez-Martínez, Marta, et al.
Publicado: (2020)

Regulation of the RNAPII Pool Is Integral to the DNA Damage Response
por: Tufegdžić Vidaković, Ana, et al.
Publicado: (2020)

Evidence that Transcript Cleavage Is Essential for RNA Polymerase II Transcription and Cell Viability
por: Sigurdsson, Stefan, et al.
Publicado: (2010)

Stability, Flexibility, and Dynamic Interactions of Colliding RNA Polymerase II Elongation Complexes
por: Saeki, Hideaki, et al.
Publicado: (2009)

Reconfiguration of Dynamic Functional Connectivity States in Patients With Lifelong Premature Ejaculation
por: Lu, Jiaming, et al.
Publicado: (2021)

Heat Shock Alters Mesenchymal Stem Cell Identity and Induces Premature Senescence
por: Shimoni, Chen, et al.
Publicado: (2020)

The Cellular Response to Transcription-Blocking DNA Damage
por: Gregersen, Lea H., et al.
Publicado: (2018)

Annotation matters: validating the discovery of cancer drivers
por: Rodríguez-Martínez, Marta, et al.
Publicado: (2020)

Yeast Smy2 and its human homologs GIGYF1 and -2 regulate Cdc48/VCP function during transcription stress
por: Lehner, Michelle Harreman, et al.
Publicado: (2022)

Antioxidants Attenuate Heat Shock Induced Premature Senescence of Bovine Mesenchymal Stem Cells
por: Nir, Dana, et al.
Publicado: (2022)

Multiomic Analysis of the UV-Induced DNA Damage Response
por: Boeing, Stefan, et al.
Publicado: (2016)

Reconfigurable Diplexer-Based Filtenna for Tx/Rx Operation in Mobile Satellite Terminals
por: Rodrigues, Luís, et al.
Publicado: (2020)

X66, a novel N-terminal heat shock protein 90 inhibitor, exerts antitumor effects without induction of heat shock response
por: Zhao, Zhixin, et al.
Publicado: (2016)

Proteasome-Mediated Processing of Def1, a Critical Step in the Cellular Response to Transcription Stress
por: Wilson, Marcus D., et al.
Publicado: (2013)

C-terminal amino acids are essential for human heat shock protein 70 dimerization
por: Marcion, Guillaume, et al.
Publicado: (2014)

Heat stress activates YAP/TAZ to induce the heat shock transcriptome
por: Luo, Min, et al.
Publicado: (2020)

DDI2 Is a Ubiquitin-Directed Endoprotease Responsible for Cleavage of Transcription Factor NRF1
por: Dirac-Svejstrup, A. Barbara, et al.
Publicado: (2020)

Heat shock protein 70-mediated sensitization of cells to apoptosis by Carboxyl-Terminal Modulator Protein
por: Piao, Longzhen, et al.
Publicado: (2009)

MultiDsk: A Ubiquitin-Specific Affinity Resin
por: Wilson, Marcus D., et al.
Publicado: (2012)

RNA Polymerase II Collision Interrupts Convergent Transcription
por: Hobson, David J., et al.
Publicado: (2012)

Shock about heat shock in cancer
por: de Billy, Emmanuel, et al.
Publicado: (2012)

Reconfigurable Logic
por: Gaillardon, Pierre-Emmanuel
Publicado: (2018)

Premature termination codons in modern human genomes
por: Fujikura, Kohei
Publicado: (2016)

Heat Shock-Induced Accumulation of Translation Elongation and Termination Factors Precedes Assembly of Stress Granules in S. cerevisiae
por: Grousl, Tomas, et al.
Publicado: (2013)

Dissecting the Functional Role of the N-Terminal Domain of the Human Small Heat Shock Protein HSPB6
por: Heirbaut, Michelle, et al.
Publicado: (2014)

Synthesis and Structure–Activity Relationships of Inhibitors That Target the C-Terminal MEEVD on Heat Shock Protein 90
por: Rahimi, Marwa N., et al.
Publicado: (2017)

The Heterooligomerization of Human Small Heat Shock Proteins Is Controlled by Conserved Motif Located in the N-Terminal Domain
por: Shatov, Vladislav M., et al.
Publicado: (2020)

The ASC-1 Complex Disassembles Collided Ribosomes
por: Juszkiewicz, Szymon, et al.
Publicado: (2020)

The Transcriptional Heat Shock Response of Salmonella Typhimurium Shows Hysteresis and Heated Cells Show Increased Resistance to Heat and Acid Stress
por: Pin, Carmen, et al.
Publicado: (2012)

Heat Shock Proteins: Stimulators of Innate and Acquired Immunity
por: Colaco, Camilo A., et al.
Publicado: (2013)

Heat shock proteins and heat shock protein-antibody complexes in placental tissues.
por: Ziegert, M, et al.
Publicado: (1999)

Cannot write session to /tmp/vufind_sessions/sess_mjv9plh71cfjqqu2pjc4rjuert