Unresolved stalled ribosome complexes restrict cell-cycle progression after genotoxic stress

During the translation surveillance mechanism known as ribosome-associated quality control, the ASC-1 complex (ASCC) disassembles ribosomes stalled on the mRNA. Here, we show that there are two distinct classes of stalled ribosome. Ribosomes stalled by translation elongation inhibitors or methylated...

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Detalles Bibliográficos
Autores principales: Stoneley, Mark, Harvey, Robert F., Mulroney, Thomas E., Mordue, Ryan, Jukes-Jones, Rebekah, Cain, Kelvin, Lilley, Kathryn S., Sawarkar, Ritwick, Willis, Anne E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098122/
https://www.ncbi.nlm.nih.gov/pubmed/35180429
http://dx.doi.org/10.1016/j.molcel.2022.01.019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098122/
https://www.ncbi.nlm.nih.gov/pubmed/35180429
http://dx.doi.org/10.1016/j.molcel.2022.01.019

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