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Unresolved stalled ribosome complexes restrict cell-cycle progression after genotoxic stress
During the translation surveillance mechanism known as ribosome-associated quality control, the ASC-1 complex (ASCC) disassembles ribosomes stalled on the mRNA. Here, we show that there are two distinct classes of stalled ribosome. Ribosomes stalled by translation elongation inhibitors or methylated...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098122/ https://www.ncbi.nlm.nih.gov/pubmed/35180429 http://dx.doi.org/10.1016/j.molcel.2022.01.019 |