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SAR of Novel 3-Arylisoquinolinones: meta-Substitution on the Aryl Ring Dramatically Enhances Antiproliferative Activity through Binding to Microtubules
[Image: see text] A set of meta-substituted 3-arylisoquinolinones have been identified that show substantial cytotoxicity in breast, liver, lung and colon cancer cell lines; these are up to 700-fold more active than the corresponding para analogues. These compounds were initially proposed as inhibit...
Autores principales: | Elhemely, Mai A., Belgath, Asma A., El-Sayed, Sherihan, Burusco, Kepa K., Kadirvel, Manikandan, Tirella, Annalisa, Finegan, Katherine, Bryce, Richard A., Stratford, Ian J., Freeman, Sally |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098178/ https://www.ncbi.nlm.nih.gov/pubmed/35290041 http://dx.doi.org/10.1021/acs.jmedchem.1c01936 |
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