Reversal of the T cell immune system reveals the molecular basis for T cell lineage fate determination in the thymus

T cell specificity and function are linked during development, as MHC-II-specific TCR signals generate CD4 helper T cells and MHC-I-specific TCR signals generate CD8 cytotoxic T cells, but the basis remains uncertain. We now report that switching coreceptor proteins encoded by Cd4 and Cd8 gene loci...

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Detalles Bibliográficos
Autores principales: Shinzawa, Miho, Moseman, E. Ashley, Gossa, Selamawit, Mano, Yasuko, Bhattacharya, Abhisek, Guinter, Terry, Alag, Amala, Chen, Xiongfong, Cam, Maggie, McGavern, Dorian B., Erman, Batu, Singer, Alfred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098387/
https://www.ncbi.nlm.nih.gov/pubmed/35523960
http://dx.doi.org/10.1038/s41590-022-01187-1

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