Pathogenic tau recruits wild-type tau into brain inclusions and induces gut degeneration in transgenic SPAM mice

Pathological tau inclusions are neuropathologic hallmarks of many neurodegenerative diseases. We generated and characterized a transgenic mouse model expressing pathogenic human tau with S320F and P301S aggregating mutations (SPAM) at transgene levels below endogenous mouse tau protein levels. This...

Descripción completa

Detalles Bibliográficos
Autores principales: Xia, Yuxing, Prokop, Stefan, Bell, Brach M., Gorion, Kimberly-Marie M., Croft, Cara L., Nasif, Lith, Xu, Guilian, Riffe, Cara J., Manaois, Alyssa N., Strang, Kevin H., Quintin, Stephan S., Paterno, Giavanna, Tansey, Malú Gámez, Borchelt, David R., Golde, Todd E., Giasson, Benoit I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098443/
https://www.ncbi.nlm.nih.gov/pubmed/35550593
http://dx.doi.org/10.1038/s42003-022-03373-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098443/
https://www.ncbi.nlm.nih.gov/pubmed/35550593
http://dx.doi.org/10.1038/s42003-022-03373-1

Ejemplares similares