Cargando…
Structure and mechanism of NALCN-FAM155A-UNC79-UNC80 channel complex
NALCN channel mediates sodium leak currents and is important for maintaining proper resting membrane potential. NALCN and FAM155A form the core complex of the channel, the activity of which essentially depends on the presence of both UNC79 and UNC80, two auxiliary proteins. NALCN, FAM155A, UNC79, an...
Autores principales: | Kang, Yunlu, Chen, Lei |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098444/ https://www.ncbi.nlm.nih.gov/pubmed/35550517 http://dx.doi.org/10.1038/s41467-022-30403-7 |
Ejemplares similares
-
Structure of voltage-modulated sodium-selective NALCN-FAM155A channel complex
por: Kang, Yunlu, et al.
Publicado: (2020) -
Intellectual disability-associated UNC80 mutations reveal inter-subunit interaction and dendritic function of the NALCN channel complex
por: Wie, Jinhong, et al.
Publicado: (2020) -
Structure of the human sodium leak channel NALCN in complex with FAM155A
por: Xie, Jiongfang, et al.
Publicado: (2020) -
The NALCN Channel Regulator UNC-80 Functions in a Subset of Interneurons To Regulate Caenorhabditis elegans Reversal Behavior
por: Zhou, Chuanman, et al.
Publicado: (2019) -
UNC79 and UNC80, Putative Auxiliary Subunits of the NARROW ABDOMEN Ion Channel, Are Indispensable for Robust Circadian Locomotor Rhythms in Drosophila
por: Lear, Bridget C., et al.
Publicado: (2013)