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The effect of perceived stress on cognition is mediated by personality and the underlying neural mechanism
Perceived stress impairs cognitive function across the adult lifespan, but the extent to which cognition decline is variable across individuals. Individual differences in the stress response are described as personality traits. Substantial individual differences in the magnitude of cognitive impairm...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098451/ https://www.ncbi.nlm.nih.gov/pubmed/35550503 http://dx.doi.org/10.1038/s41398-022-01929-7 |
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author | Zhu, Ximei Yan, Wei Lin, Xiao Que, Jianyu Huang, Yuetong Zheng, Haohao Liu, Lin Deng, Jiahui Lu, Lin Chang, Suhua |
author_facet | Zhu, Ximei Yan, Wei Lin, Xiao Que, Jianyu Huang, Yuetong Zheng, Haohao Liu, Lin Deng, Jiahui Lu, Lin Chang, Suhua |
author_sort | Zhu, Ximei |
collection | PubMed |
description | Perceived stress impairs cognitive function across the adult lifespan, but the extent to which cognition decline is variable across individuals. Individual differences in the stress response are described as personality traits. Substantial individual differences in the magnitude of cognitive impairment that is induced by short-term perceived stress are poorly understood. The present study tested the hypothesis that the relationship between short-term perceived stress and different aspects of cognition is mediated by personality traits. The study included 1066 participants with behavior and neuroimaging data from the Human Connectome Project after excluding individuals with missing variables. In the result, the parallel multiple mediation model demonstrated that the influence of perceived stress on the total and crystalized cognition is mainly mediated by neuroticism (indirect effect = −0.04, p < 0.05) and conscientiousness (indirect effect = 0.05, p < 0.05) in adults. Cortical thickness value (n = 1066) of the right superior frontal gyrus (SFG) showed not only positive correlations with short-term perceived stress and neuroticism, but negative associations with cognition. The chain mediation model found that the right SFG and neuroticism play a small but significant chain mediating effect between stress and total cognition. The strength of the resting-state functional connectivity (n = 968) between the left orbitofrontal cortex versus the left superior medial frontal cortex was positively correlated with crystallized cognition and negatively associated with conscientiousness. These results extend previous findings by the impacts of short-term perceived stress on cognitive function is mediated by neuroticism and the right SFG was the underlying neural mechanism. |
format | Online Article Text |
id | pubmed-9098451 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-90984512022-05-14 The effect of perceived stress on cognition is mediated by personality and the underlying neural mechanism Zhu, Ximei Yan, Wei Lin, Xiao Que, Jianyu Huang, Yuetong Zheng, Haohao Liu, Lin Deng, Jiahui Lu, Lin Chang, Suhua Transl Psychiatry Article Perceived stress impairs cognitive function across the adult lifespan, but the extent to which cognition decline is variable across individuals. Individual differences in the stress response are described as personality traits. Substantial individual differences in the magnitude of cognitive impairment that is induced by short-term perceived stress are poorly understood. The present study tested the hypothesis that the relationship between short-term perceived stress and different aspects of cognition is mediated by personality traits. The study included 1066 participants with behavior and neuroimaging data from the Human Connectome Project after excluding individuals with missing variables. In the result, the parallel multiple mediation model demonstrated that the influence of perceived stress on the total and crystalized cognition is mainly mediated by neuroticism (indirect effect = −0.04, p < 0.05) and conscientiousness (indirect effect = 0.05, p < 0.05) in adults. Cortical thickness value (n = 1066) of the right superior frontal gyrus (SFG) showed not only positive correlations with short-term perceived stress and neuroticism, but negative associations with cognition. The chain mediation model found that the right SFG and neuroticism play a small but significant chain mediating effect between stress and total cognition. The strength of the resting-state functional connectivity (n = 968) between the left orbitofrontal cortex versus the left superior medial frontal cortex was positively correlated with crystallized cognition and negatively associated with conscientiousness. These results extend previous findings by the impacts of short-term perceived stress on cognitive function is mediated by neuroticism and the right SFG was the underlying neural mechanism. Nature Publishing Group UK 2022-05-12 /pmc/articles/PMC9098451/ /pubmed/35550503 http://dx.doi.org/10.1038/s41398-022-01929-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Zhu, Ximei Yan, Wei Lin, Xiao Que, Jianyu Huang, Yuetong Zheng, Haohao Liu, Lin Deng, Jiahui Lu, Lin Chang, Suhua The effect of perceived stress on cognition is mediated by personality and the underlying neural mechanism |
title | The effect of perceived stress on cognition is mediated by personality and the underlying neural mechanism |
title_full | The effect of perceived stress on cognition is mediated by personality and the underlying neural mechanism |
title_fullStr | The effect of perceived stress on cognition is mediated by personality and the underlying neural mechanism |
title_full_unstemmed | The effect of perceived stress on cognition is mediated by personality and the underlying neural mechanism |
title_short | The effect of perceived stress on cognition is mediated by personality and the underlying neural mechanism |
title_sort | effect of perceived stress on cognition is mediated by personality and the underlying neural mechanism |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098451/ https://www.ncbi.nlm.nih.gov/pubmed/35550503 http://dx.doi.org/10.1038/s41398-022-01929-7 |
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