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Active conformation of the p97-p47 unfoldase complex

The p97 AAA+ATPase is an essential and abundant regulator of protein homeostasis that plays a central role in unfolding ubiquitylated substrates. Here we report two cryo-EM structures of human p97 in complex with its p47 adaptor. One of the conformations is six-fold symmetric, corresponds to previou...

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Detalles Bibliográficos
Autores principales:	Xu, Yang, Han, Han, Cooney, Ian, Guo, Yuxuan, Moran, Noah G., Zuniga, Nathan R., Price, John C., Hill, Christopher P., Shen, Peter S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098461/ https://www.ncbi.nlm.nih.gov/pubmed/35552390 http://dx.doi.org/10.1038/s41467-022-30318-3

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