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Distributed implantation of a flexible microelectrode array for neural recording

Flexible multichannel electrode arrays (fMEAs) with multiple filaments can be flexibly implanted in various patterns. It is necessary to develop a method for implanting the fMEA in different locations and at various depths based on the recording demands. This study proposed a strategy for reducing t...

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Autores principales: Wei, Chunrong, Wang, Yang, Pei, Weihua, Han, Xinyong, Lin, Longnian, Liu, Zhiduo, Ming, Gege, Chen, Ruru, Wu, Pingping, Yang, Xiaowei, Zheng, Li, Wang, Yijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098495/
https://www.ncbi.nlm.nih.gov/pubmed/35572780
http://dx.doi.org/10.1038/s41378-022-00366-2
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author Wei, Chunrong
Wang, Yang
Pei, Weihua
Han, Xinyong
Lin, Longnian
Liu, Zhiduo
Ming, Gege
Chen, Ruru
Wu, Pingping
Yang, Xiaowei
Zheng, Li
Wang, Yijun
author_facet Wei, Chunrong
Wang, Yang
Pei, Weihua
Han, Xinyong
Lin, Longnian
Liu, Zhiduo
Ming, Gege
Chen, Ruru
Wu, Pingping
Yang, Xiaowei
Zheng, Li
Wang, Yijun
author_sort Wei, Chunrong
collection PubMed
description Flexible multichannel electrode arrays (fMEAs) with multiple filaments can be flexibly implanted in various patterns. It is necessary to develop a method for implanting the fMEA in different locations and at various depths based on the recording demands. This study proposed a strategy for reducing the microelectrode volume with integrated packaging. An implantation system was developed specifically for semiautomatic distributed implantation. The feasibility and convenience of the fMEA and implantation platform were verified in rodents. The acute and chronic recording results provied the effectiveness of the packaging and implantation methods. These methods could provide a novel strategy for developing fMEAs with more filaments and recording sites to measure functional interactions across multiple brain regions.
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spelling pubmed-90984952022-05-14 Distributed implantation of a flexible microelectrode array for neural recording Wei, Chunrong Wang, Yang Pei, Weihua Han, Xinyong Lin, Longnian Liu, Zhiduo Ming, Gege Chen, Ruru Wu, Pingping Yang, Xiaowei Zheng, Li Wang, Yijun Microsyst Nanoeng Article Flexible multichannel electrode arrays (fMEAs) with multiple filaments can be flexibly implanted in various patterns. It is necessary to develop a method for implanting the fMEA in different locations and at various depths based on the recording demands. This study proposed a strategy for reducing the microelectrode volume with integrated packaging. An implantation system was developed specifically for semiautomatic distributed implantation. The feasibility and convenience of the fMEA and implantation platform were verified in rodents. The acute and chronic recording results provied the effectiveness of the packaging and implantation methods. These methods could provide a novel strategy for developing fMEAs with more filaments and recording sites to measure functional interactions across multiple brain regions. Nature Publishing Group UK 2022-05-12 /pmc/articles/PMC9098495/ /pubmed/35572780 http://dx.doi.org/10.1038/s41378-022-00366-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Wei, Chunrong
Wang, Yang
Pei, Weihua
Han, Xinyong
Lin, Longnian
Liu, Zhiduo
Ming, Gege
Chen, Ruru
Wu, Pingping
Yang, Xiaowei
Zheng, Li
Wang, Yijun
Distributed implantation of a flexible microelectrode array for neural recording
title Distributed implantation of a flexible microelectrode array for neural recording
title_full Distributed implantation of a flexible microelectrode array for neural recording
title_fullStr Distributed implantation of a flexible microelectrode array for neural recording
title_full_unstemmed Distributed implantation of a flexible microelectrode array for neural recording
title_short Distributed implantation of a flexible microelectrode array for neural recording
title_sort distributed implantation of a flexible microelectrode array for neural recording
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098495/
https://www.ncbi.nlm.nih.gov/pubmed/35572780
http://dx.doi.org/10.1038/s41378-022-00366-2
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