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The therapeutic potential of RNA Polymerase I transcription inhibitor, CX-5461, in uterine leiomyosarcoma

Background. Uterine leiomyosarcoma is a rare aggressive smooth muscle cancer with poor survival rates. RNA Polymerase I (Pol I) activity is elevated in many cancers supporting tumour growth and prior studies in uterine leiomyosarcoma revealed enlarged nucleoli and upregulated Pol I activity-related...

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Detalles Bibliográficos
Autores principales:	Kang, Chang-Won, Hannan, Katherine M., Blackburn, Anneke C., Loh, Amos H. P., Hong, Kuick Chik, Yuan, Goh Jian, Hein, Nadine, Drygin, Denis, Hannan, Ross D., Coupland, Lucy A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2022
Materias:	Preclinical Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098598/ https://www.ncbi.nlm.nih.gov/pubmed/35201535 http://dx.doi.org/10.1007/s10637-022-01222-w

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