Case Report: Development of Diffuse Large B Cell Lymphoma a Long Time After Hairy Cell Leukemia

Hairy cell leukaemia (HCL) is a rare B cell malignancy with an indolent course leading to pancytopaenia due to bone marrow infiltration. It has been proposed that HCL patients are at risk of developing a secondary malignancy, with a marked likelihood of the development of other hematologic malignanc...

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Autores principales: Nagy, Zsófia F., Ferenczi, Kata, Istenes, Ildikó, Eid, Hanna, Bödör, Csaba, Timár, Botond, Demeter, Judit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pathology and Oncology Archive
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098676/
https://www.ncbi.nlm.nih.gov/pubmed/35570843
http://dx.doi.org/10.3389/pore.2022.1610338
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author Nagy, Zsófia F.
Ferenczi, Kata
Istenes, Ildikó
Eid, Hanna
Bödör, Csaba
Timár, Botond
Demeter, Judit
author_facet Nagy, Zsófia F.
Ferenczi, Kata
Istenes, Ildikó
Eid, Hanna
Bödör, Csaba
Timár, Botond
Demeter, Judit
author_sort Nagy, Zsófia F.
collection PubMed
description Hairy cell leukaemia (HCL) is a rare B cell malignancy with an indolent course leading to pancytopaenia due to bone marrow infiltration. It has been proposed that HCL patients are at risk of developing a secondary malignancy, with a marked likelihood of the development of other hematologic malignancies including Hodgkin lymphoma and high-grade non-Hodgkin lymphomas. Here, we present the case of two patients who developed diffuse large B cell lymphoma after a long course of hairy cell leukaemia. In the case of the female patient, we report on the occurrence of a third malignant disease, which is very uncommon. With our case descriptions we contribute to the very small number of similar cases reported.
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spelling pubmed-90986762022-05-14 Case Report: Development of Diffuse Large B Cell Lymphoma a Long Time After Hairy Cell Leukemia Nagy, Zsófia F. Ferenczi, Kata Istenes, Ildikó Eid, Hanna Bödör, Csaba Timár, Botond Demeter, Judit Pathol Oncol Res Pathology and Oncology Archive Hairy cell leukaemia (HCL) is a rare B cell malignancy with an indolent course leading to pancytopaenia due to bone marrow infiltration. It has been proposed that HCL patients are at risk of developing a secondary malignancy, with a marked likelihood of the development of other hematologic malignancies including Hodgkin lymphoma and high-grade non-Hodgkin lymphomas. Here, we present the case of two patients who developed diffuse large B cell lymphoma after a long course of hairy cell leukaemia. In the case of the female patient, we report on the occurrence of a third malignant disease, which is very uncommon. With our case descriptions we contribute to the very small number of similar cases reported. Frontiers Media S.A. 2022-04-29 /pmc/articles/PMC9098676/ /pubmed/35570843 http://dx.doi.org/10.3389/pore.2022.1610338 Text en Copyright © 2022 Nagy, Ferenczi, Istenes, Eid, Bödör, Timár and Demeter. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pathology and Oncology Archive
Nagy, Zsófia F.
Ferenczi, Kata
Istenes, Ildikó
Eid, Hanna
Bödör, Csaba
Timár, Botond
Demeter, Judit
Case Report: Development of Diffuse Large B Cell Lymphoma a Long Time After Hairy Cell Leukemia
title Case Report: Development of Diffuse Large B Cell Lymphoma a Long Time After Hairy Cell Leukemia
title_full Case Report: Development of Diffuse Large B Cell Lymphoma a Long Time After Hairy Cell Leukemia
title_fullStr Case Report: Development of Diffuse Large B Cell Lymphoma a Long Time After Hairy Cell Leukemia
title_full_unstemmed Case Report: Development of Diffuse Large B Cell Lymphoma a Long Time After Hairy Cell Leukemia
title_short Case Report: Development of Diffuse Large B Cell Lymphoma a Long Time After Hairy Cell Leukemia
title_sort case report: development of diffuse large b cell lymphoma a long time after hairy cell leukemia
topic Pathology and Oncology Archive
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098676/
https://www.ncbi.nlm.nih.gov/pubmed/35570843
http://dx.doi.org/10.3389/pore.2022.1610338
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