Current Role of Allogeneic Stem Cell Transplantation in Multiple Myeloma

Major progress in the treatment of multiple myeloma has been made in the last several years. However, myeloma remains incurable and patients with high-risk cytogenetics or advanced stage disease have an even worsen survival. Only allogeneic transplantation may have curative potential in some patient...

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Autores principales: Claveau, Jean-Sébastien, Buadi, Francis K., Kumar, Shaji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098709/
https://www.ncbi.nlm.nih.gov/pubmed/35377068
http://dx.doi.org/10.1007/s40487-022-00195-3
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author Claveau, Jean-Sébastien
Buadi, Francis K.
Kumar, Shaji
author_facet Claveau, Jean-Sébastien
Buadi, Francis K.
Kumar, Shaji
author_sort Claveau, Jean-Sébastien
collection PubMed
description Major progress in the treatment of multiple myeloma has been made in the last several years. However, myeloma remains incurable and patients with high-risk cytogenetics or advanced stage disease have an even worsen survival. Only allogeneic transplantation may have curative potential in some patients. However, the high non-relapse mortality and incidence of chronic graft-versus-host disease have raised controversy regarding this procedure. In this review, we will address the role of upfront and delayed allogeneic transplant.
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spelling pubmed-90987092022-05-14 Current Role of Allogeneic Stem Cell Transplantation in Multiple Myeloma Claveau, Jean-Sébastien Buadi, Francis K. Kumar, Shaji Oncol Ther Review Major progress in the treatment of multiple myeloma has been made in the last several years. However, myeloma remains incurable and patients with high-risk cytogenetics or advanced stage disease have an even worsen survival. Only allogeneic transplantation may have curative potential in some patients. However, the high non-relapse mortality and incidence of chronic graft-versus-host disease have raised controversy regarding this procedure. In this review, we will address the role of upfront and delayed allogeneic transplant. Springer Healthcare 2022-04-04 /pmc/articles/PMC9098709/ /pubmed/35377068 http://dx.doi.org/10.1007/s40487-022-00195-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Review
Claveau, Jean-Sébastien
Buadi, Francis K.
Kumar, Shaji
Current Role of Allogeneic Stem Cell Transplantation in Multiple Myeloma
title Current Role of Allogeneic Stem Cell Transplantation in Multiple Myeloma
title_full Current Role of Allogeneic Stem Cell Transplantation in Multiple Myeloma
title_fullStr Current Role of Allogeneic Stem Cell Transplantation in Multiple Myeloma
title_full_unstemmed Current Role of Allogeneic Stem Cell Transplantation in Multiple Myeloma
title_short Current Role of Allogeneic Stem Cell Transplantation in Multiple Myeloma
title_sort current role of allogeneic stem cell transplantation in multiple myeloma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098709/
https://www.ncbi.nlm.nih.gov/pubmed/35377068
http://dx.doi.org/10.1007/s40487-022-00195-3
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