Lignans and sesquiterpenoids from the stems of Schisandra bicolor var. tuberculata

A pair of new tetrahydrofuran lignan enantiomers, (±)-schibiculatin A [(±)-1], a new enedione lignan, schibiculatin B (2), two new cadinane-type sesquiterpenoids, schibiculatins C (3) and D (4), along with two known seco-cadinane-type sesquiterpenoids (5 and 6) and seven known miscellaneous lignans...

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Autores principales: Zhang, Shui-Mei, Hu, Kun, Li, Xiao-Nian, Sun, Han-Dong, Puno, Pema-Tenzin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098724/
https://www.ncbi.nlm.nih.gov/pubmed/35552885
http://dx.doi.org/10.1007/s13659-022-00342-3
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author Zhang, Shui-Mei
Hu, Kun
Li, Xiao-Nian
Sun, Han-Dong
Puno, Pema-Tenzin
author_facet Zhang, Shui-Mei
Hu, Kun
Li, Xiao-Nian
Sun, Han-Dong
Puno, Pema-Tenzin
author_sort Zhang, Shui-Mei
collection PubMed
description A pair of new tetrahydrofuran lignan enantiomers, (±)-schibiculatin A [(±)-1], a new enedione lignan, schibiculatin B (2), two new cadinane-type sesquiterpenoids, schibiculatins C (3) and D (4), along with two known seco-cadinane-type sesquiterpenoids (5 and 6) and seven known miscellaneous lignans (7–13) were isolated from the stems of Schisandra bicolor var. tuberculata. The structures of 1–4 were elucidated by comprehensive analysis of their spectroscopic data, quantum chemical calculations, as well as single-crystal X-ray diffraction. A few isolated compounds were tested for their protective activities against corticosterone-induced apoptosis in PC12 cells. Among them, compounds 5 and 6 showed moderate activities. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13659-022-00342-3.
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spelling pubmed-90987242022-05-14 Lignans and sesquiterpenoids from the stems of Schisandra bicolor var. tuberculata Zhang, Shui-Mei Hu, Kun Li, Xiao-Nian Sun, Han-Dong Puno, Pema-Tenzin Nat Prod Bioprospect Original Article A pair of new tetrahydrofuran lignan enantiomers, (±)-schibiculatin A [(±)-1], a new enedione lignan, schibiculatin B (2), two new cadinane-type sesquiterpenoids, schibiculatins C (3) and D (4), along with two known seco-cadinane-type sesquiterpenoids (5 and 6) and seven known miscellaneous lignans (7–13) were isolated from the stems of Schisandra bicolor var. tuberculata. The structures of 1–4 were elucidated by comprehensive analysis of their spectroscopic data, quantum chemical calculations, as well as single-crystal X-ray diffraction. A few isolated compounds were tested for their protective activities against corticosterone-induced apoptosis in PC12 cells. Among them, compounds 5 and 6 showed moderate activities. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13659-022-00342-3. Springer Nature Singapore 2022-05-13 /pmc/articles/PMC9098724/ /pubmed/35552885 http://dx.doi.org/10.1007/s13659-022-00342-3 Text en © The Author(s) 2022, corrected publication https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Zhang, Shui-Mei
Hu, Kun
Li, Xiao-Nian
Sun, Han-Dong
Puno, Pema-Tenzin
Lignans and sesquiterpenoids from the stems of Schisandra bicolor var. tuberculata
title Lignans and sesquiterpenoids from the stems of Schisandra bicolor var. tuberculata
title_full Lignans and sesquiterpenoids from the stems of Schisandra bicolor var. tuberculata
title_fullStr Lignans and sesquiterpenoids from the stems of Schisandra bicolor var. tuberculata
title_full_unstemmed Lignans and sesquiterpenoids from the stems of Schisandra bicolor var. tuberculata
title_short Lignans and sesquiterpenoids from the stems of Schisandra bicolor var. tuberculata
title_sort lignans and sesquiterpenoids from the stems of schisandra bicolor var. tuberculata
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098724/
https://www.ncbi.nlm.nih.gov/pubmed/35552885
http://dx.doi.org/10.1007/s13659-022-00342-3
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