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Liquid Biopsy in Squamous Cell Carcinoma of the Esophagus and of the Head and Neck
Squamous cell carcinomas of the esophagus (ESCC) and of the head and neck (HNSCC) are two neoplasms that share common risk factors and have the same embryological origin, but a very different prognosis, the 5-year survival of HNSCC being almost double (40–50%) compared to the 5-year survival of ESCC...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098838/ https://www.ncbi.nlm.nih.gov/pubmed/35572996 http://dx.doi.org/10.3389/fmed.2022.827297 |
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author | Iacob, Razvan Mandea, Matei Iacob, Speranta Pietrosanu, Catalina Paul, Doru Hainarosie, Razvan Gheorghe, Cristian |
author_facet | Iacob, Razvan Mandea, Matei Iacob, Speranta Pietrosanu, Catalina Paul, Doru Hainarosie, Razvan Gheorghe, Cristian |
author_sort | Iacob, Razvan |
collection | PubMed |
description | Squamous cell carcinomas of the esophagus (ESCC) and of the head and neck (HNSCC) are two neoplasms that share common risk factors and have the same embryological origin, but a very different prognosis, the 5-year survival of HNSCC being almost double (40–50%) compared to the 5-year survival of ESCC (20%). Current guidelines emphasize the importance of screening for ESCC in patients diagnosed with head and neck cancers. A liquid biopsy is a novel tool for diagnosis, prognostic stratification, and personalized therapy. Liquid biopsy biomarkers for these two malignancies could help both their early detection, facilitate residual disease identification, and provide prognosis information. The present systematic review of the literature was aimed at describing the liquid biopsy biomarkers present in these two malignancies, with an emphasis on potential clinical applications. |
format | Online Article Text |
id | pubmed-9098838 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90988382022-05-14 Liquid Biopsy in Squamous Cell Carcinoma of the Esophagus and of the Head and Neck Iacob, Razvan Mandea, Matei Iacob, Speranta Pietrosanu, Catalina Paul, Doru Hainarosie, Razvan Gheorghe, Cristian Front Med (Lausanne) Medicine Squamous cell carcinomas of the esophagus (ESCC) and of the head and neck (HNSCC) are two neoplasms that share common risk factors and have the same embryological origin, but a very different prognosis, the 5-year survival of HNSCC being almost double (40–50%) compared to the 5-year survival of ESCC (20%). Current guidelines emphasize the importance of screening for ESCC in patients diagnosed with head and neck cancers. A liquid biopsy is a novel tool for diagnosis, prognostic stratification, and personalized therapy. Liquid biopsy biomarkers for these two malignancies could help both their early detection, facilitate residual disease identification, and provide prognosis information. The present systematic review of the literature was aimed at describing the liquid biopsy biomarkers present in these two malignancies, with an emphasis on potential clinical applications. Frontiers Media S.A. 2022-04-29 /pmc/articles/PMC9098838/ /pubmed/35572996 http://dx.doi.org/10.3389/fmed.2022.827297 Text en Copyright © 2022 Iacob, Mandea, Iacob, Pietrosanu, Paul, Hainarosie and Gheorghe. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Iacob, Razvan Mandea, Matei Iacob, Speranta Pietrosanu, Catalina Paul, Doru Hainarosie, Razvan Gheorghe, Cristian Liquid Biopsy in Squamous Cell Carcinoma of the Esophagus and of the Head and Neck |
title | Liquid Biopsy in Squamous Cell Carcinoma of the Esophagus and of the Head and Neck |
title_full | Liquid Biopsy in Squamous Cell Carcinoma of the Esophagus and of the Head and Neck |
title_fullStr | Liquid Biopsy in Squamous Cell Carcinoma of the Esophagus and of the Head and Neck |
title_full_unstemmed | Liquid Biopsy in Squamous Cell Carcinoma of the Esophagus and of the Head and Neck |
title_short | Liquid Biopsy in Squamous Cell Carcinoma of the Esophagus and of the Head and Neck |
title_sort | liquid biopsy in squamous cell carcinoma of the esophagus and of the head and neck |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098838/ https://www.ncbi.nlm.nih.gov/pubmed/35572996 http://dx.doi.org/10.3389/fmed.2022.827297 |
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