snoRNAs: functions and mechanisms in biological processes, and roles in tumor pathophysiology

Small nucleolar RNAs (snoRNAs), a type of non-coding RNA, are widely present in the nucleoli of eukaryotic cells and play an important role in rRNA modification. With the recent increase in research on snoRNAs, new evidence has emerged indicating that snoRNAs also participate in tRNA and mRNA modifi...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Zheng-hao, Du, Yu-ping, Wen, Jing-tao, Lu, Bing-feng, Zhao, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098889/
https://www.ncbi.nlm.nih.gov/pubmed/35552378
http://dx.doi.org/10.1038/s41420-022-01056-8
_version_ 1784706479307096064
author Huang, Zheng-hao
Du, Yu-ping
Wen, Jing-tao
Lu, Bing-feng
Zhao, Yang
author_facet Huang, Zheng-hao
Du, Yu-ping
Wen, Jing-tao
Lu, Bing-feng
Zhao, Yang
author_sort Huang, Zheng-hao
collection PubMed
description Small nucleolar RNAs (snoRNAs), a type of non-coding RNA, are widely present in the nucleoli of eukaryotic cells and play an important role in rRNA modification. With the recent increase in research on snoRNAs, new evidence has emerged indicating that snoRNAs also participate in tRNA and mRNA modification. Studies suggest that numerous snoRNAs, including tumor-promoting and tumor-suppressing snoRNAs, are not only dysregulated in tumors but also show associations with clinical prognosis. In this review, we summarize the reported functions of snoRNAs and the possible mechanisms underlying their role in tumorigenesis and cancer development to guide the snoRNA-based clinical diagnosis and treatment of cancer in the future.
format Online
Article
Text
id pubmed-9098889
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-90988892022-05-14 snoRNAs: functions and mechanisms in biological processes, and roles in tumor pathophysiology Huang, Zheng-hao Du, Yu-ping Wen, Jing-tao Lu, Bing-feng Zhao, Yang Cell Death Discov Review Article Small nucleolar RNAs (snoRNAs), a type of non-coding RNA, are widely present in the nucleoli of eukaryotic cells and play an important role in rRNA modification. With the recent increase in research on snoRNAs, new evidence has emerged indicating that snoRNAs also participate in tRNA and mRNA modification. Studies suggest that numerous snoRNAs, including tumor-promoting and tumor-suppressing snoRNAs, are not only dysregulated in tumors but also show associations with clinical prognosis. In this review, we summarize the reported functions of snoRNAs and the possible mechanisms underlying their role in tumorigenesis and cancer development to guide the snoRNA-based clinical diagnosis and treatment of cancer in the future. Nature Publishing Group UK 2022-05-12 /pmc/articles/PMC9098889/ /pubmed/35552378 http://dx.doi.org/10.1038/s41420-022-01056-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Huang, Zheng-hao
Du, Yu-ping
Wen, Jing-tao
Lu, Bing-feng
Zhao, Yang
snoRNAs: functions and mechanisms in biological processes, and roles in tumor pathophysiology
title snoRNAs: functions and mechanisms in biological processes, and roles in tumor pathophysiology
title_full snoRNAs: functions and mechanisms in biological processes, and roles in tumor pathophysiology
title_fullStr snoRNAs: functions and mechanisms in biological processes, and roles in tumor pathophysiology
title_full_unstemmed snoRNAs: functions and mechanisms in biological processes, and roles in tumor pathophysiology
title_short snoRNAs: functions and mechanisms in biological processes, and roles in tumor pathophysiology
title_sort snornas: functions and mechanisms in biological processes, and roles in tumor pathophysiology
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098889/
https://www.ncbi.nlm.nih.gov/pubmed/35552378
http://dx.doi.org/10.1038/s41420-022-01056-8
work_keys_str_mv AT huangzhenghao snornasfunctionsandmechanismsinbiologicalprocessesandrolesintumorpathophysiology
AT duyuping snornasfunctionsandmechanismsinbiologicalprocessesandrolesintumorpathophysiology
AT wenjingtao snornasfunctionsandmechanismsinbiologicalprocessesandrolesintumorpathophysiology
AT lubingfeng snornasfunctionsandmechanismsinbiologicalprocessesandrolesintumorpathophysiology
AT zhaoyang snornasfunctionsandmechanismsinbiologicalprocessesandrolesintumorpathophysiology

Ejemplares similares