CDK12 promotes tumorigenesis but induces vulnerability to therapies inhibiting folate one-carbon metabolism in breast cancer

Cyclin-dependent kinase 12 (CDK12) overexpression is implicated in breast cancer, but whether it has a primary or only a cooperative tumorigenic role is unclear. Here, we show that transgenic CDK12 overexpression in the mouse mammary gland per se is sufficient to drive the emergence of multiple and...

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Detalles Bibliográficos
Autores principales: Filippone, M. G., Gaglio, D., Bonfanti, R., Tucci, F. A., Ceccacci, E., Pennisi, R., Bonanomi, M., Jodice, G., Tillhon, M., Montani, F., Bertalot, G., Freddi, S., Vecchi, M., Taglialatela, A., Romanenghi, M., Romeo, F., Bianco, N., Munzone, E., Sanguedolce, F., Vago, G., Viale, G., Di Fiore, P. P., Minucci, S., Alberghina, L., Colleoni, M., Veronesi, P., Tosoni, D., Pece, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098894/
https://www.ncbi.nlm.nih.gov/pubmed/35550508
http://dx.doi.org/10.1038/s41467-022-30375-8

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