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Assessing Obesity-Related Adipose Tissue Disease (OrAD) to Improve Precision Medicine for Patients Living With Obesity

Obesity is a heterogenous condition that affects the life and health of patients to different degrees and in different ways. Yet, most approaches to treat obesity are not currently prescribed, at least in a systematic manner, based on individual obesity sub-phenotypes or specifically-predicted healt...

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Autores principales: Pincu, Yair, Yoel, Uri, Haim, Yulia, Makarenkov, Nataly, Maixner, Nitzan, Shaco-Levy, Ruthy, Bashan, Nava, Dicker, Dror, Rudich, Assaf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098964/
https://www.ncbi.nlm.nih.gov/pubmed/35574032
http://dx.doi.org/10.3389/fendo.2022.860799
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author Pincu, Yair
Yoel, Uri
Haim, Yulia
Makarenkov, Nataly
Maixner, Nitzan
Shaco-Levy, Ruthy
Bashan, Nava
Dicker, Dror
Rudich, Assaf
author_facet Pincu, Yair
Yoel, Uri
Haim, Yulia
Makarenkov, Nataly
Maixner, Nitzan
Shaco-Levy, Ruthy
Bashan, Nava
Dicker, Dror
Rudich, Assaf
author_sort Pincu, Yair
collection PubMed
description Obesity is a heterogenous condition that affects the life and health of patients to different degrees and in different ways. Yet, most approaches to treat obesity are not currently prescribed, at least in a systematic manner, based on individual obesity sub-phenotypes or specifically-predicted health risks. Adipose tissue is one of the most evidently affected tissues in obesity. The degree of adipose tissue changes – “adiposopathy”, or as we propose to relate to herein as Obesity-related Adipose tissue Disease (OrAD), correspond, at least cross-sectionally, to the extent of obesity-related complications inflicted on an individual patient. This potentially provides an opportunity to better personalize anti-obesity management by utilizing the information that can be retrieved by assessing OrAD. This review article will summarize current knowledge on histopathological OrAD features which, beyond cross-sectional analyses, had been shown to predict future obesity-related endpoints and/or the response to specific anti-obesity interventions. In particular, the review explores adipocyte cell size, adipose tissue inflammation, and fibrosis. Rather than highly-specialized methods, we emphasize standard pathology laboratory approaches to assess OrAD, which are readily-available in most clinical settings. We then discuss how OrAD assessment can be streamlined in the obesity/weight-management clinic. We propose that current studies provide sufficient evidence to inspire concerted efforts to better explore the possibility of predicting obesity related clinical endpoints and response to interventions by histological OrAD assessment, in the quest to improve precision medicine in obesity.
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spelling pubmed-90989642022-05-14 Assessing Obesity-Related Adipose Tissue Disease (OrAD) to Improve Precision Medicine for Patients Living With Obesity Pincu, Yair Yoel, Uri Haim, Yulia Makarenkov, Nataly Maixner, Nitzan Shaco-Levy, Ruthy Bashan, Nava Dicker, Dror Rudich, Assaf Front Endocrinol (Lausanne) Endocrinology Obesity is a heterogenous condition that affects the life and health of patients to different degrees and in different ways. Yet, most approaches to treat obesity are not currently prescribed, at least in a systematic manner, based on individual obesity sub-phenotypes or specifically-predicted health risks. Adipose tissue is one of the most evidently affected tissues in obesity. The degree of adipose tissue changes – “adiposopathy”, or as we propose to relate to herein as Obesity-related Adipose tissue Disease (OrAD), correspond, at least cross-sectionally, to the extent of obesity-related complications inflicted on an individual patient. This potentially provides an opportunity to better personalize anti-obesity management by utilizing the information that can be retrieved by assessing OrAD. This review article will summarize current knowledge on histopathological OrAD features which, beyond cross-sectional analyses, had been shown to predict future obesity-related endpoints and/or the response to specific anti-obesity interventions. In particular, the review explores adipocyte cell size, adipose tissue inflammation, and fibrosis. Rather than highly-specialized methods, we emphasize standard pathology laboratory approaches to assess OrAD, which are readily-available in most clinical settings. We then discuss how OrAD assessment can be streamlined in the obesity/weight-management clinic. We propose that current studies provide sufficient evidence to inspire concerted efforts to better explore the possibility of predicting obesity related clinical endpoints and response to interventions by histological OrAD assessment, in the quest to improve precision medicine in obesity. Frontiers Media S.A. 2022-04-29 /pmc/articles/PMC9098964/ /pubmed/35574032 http://dx.doi.org/10.3389/fendo.2022.860799 Text en Copyright © 2022 Pincu, Yoel, Haim, Makarenkov, Maixner, Shaco-Levy, Bashan, Dicker and Rudich https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Pincu, Yair
Yoel, Uri
Haim, Yulia
Makarenkov, Nataly
Maixner, Nitzan
Shaco-Levy, Ruthy
Bashan, Nava
Dicker, Dror
Rudich, Assaf
Assessing Obesity-Related Adipose Tissue Disease (OrAD) to Improve Precision Medicine for Patients Living With Obesity
title Assessing Obesity-Related Adipose Tissue Disease (OrAD) to Improve Precision Medicine for Patients Living With Obesity
title_full Assessing Obesity-Related Adipose Tissue Disease (OrAD) to Improve Precision Medicine for Patients Living With Obesity
title_fullStr Assessing Obesity-Related Adipose Tissue Disease (OrAD) to Improve Precision Medicine for Patients Living With Obesity
title_full_unstemmed Assessing Obesity-Related Adipose Tissue Disease (OrAD) to Improve Precision Medicine for Patients Living With Obesity
title_short Assessing Obesity-Related Adipose Tissue Disease (OrAD) to Improve Precision Medicine for Patients Living With Obesity
title_sort assessing obesity-related adipose tissue disease (orad) to improve precision medicine for patients living with obesity
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098964/
https://www.ncbi.nlm.nih.gov/pubmed/35574032
http://dx.doi.org/10.3389/fendo.2022.860799
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