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Lactate Is Answerable for Brain Function and Treating Brain Diseases: Energy Substrates and Signal Molecule
Research to date has provided novel insights into lactate's positive role in multiple brain functions and several brain diseases. Although notable controversies and discrepancies remain, the neurobiological role and the metabolic mechanisms of brain lactate have now been described. A theoretica...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099001/ https://www.ncbi.nlm.nih.gov/pubmed/35571940 http://dx.doi.org/10.3389/fnut.2022.800901 |
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author | Cai, Ming Wang, Hongbiao Song, Haihan Yang, Ruoyu Wang, Liyan Xue, Xiangli Sun, Wanju Hu, Jingyun |
author_facet | Cai, Ming Wang, Hongbiao Song, Haihan Yang, Ruoyu Wang, Liyan Xue, Xiangli Sun, Wanju Hu, Jingyun |
author_sort | Cai, Ming |
collection | PubMed |
description | Research to date has provided novel insights into lactate's positive role in multiple brain functions and several brain diseases. Although notable controversies and discrepancies remain, the neurobiological role and the metabolic mechanisms of brain lactate have now been described. A theoretical framework on the relevance between lactate and brain function and brain diseases is presented. This review begins with the source and route of lactate formation in the brain and food; goes on to uncover the regulatory effect of lactate on brain function; and progresses to gathering the application and concentration variation of lactate in several brain diseases (diabetic encephalopathy, Alzheimer's disease, stroke, traumatic brain injury, and epilepsy) treatment. Finally, the dual role of lactate in the brain is discussed. This review highlights the biological effect of lactate, especially L-lactate, in brain function and disease studies and amplifies our understanding of past research. |
format | Online Article Text |
id | pubmed-9099001 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90990012022-05-14 Lactate Is Answerable for Brain Function and Treating Brain Diseases: Energy Substrates and Signal Molecule Cai, Ming Wang, Hongbiao Song, Haihan Yang, Ruoyu Wang, Liyan Xue, Xiangli Sun, Wanju Hu, Jingyun Front Nutr Nutrition Research to date has provided novel insights into lactate's positive role in multiple brain functions and several brain diseases. Although notable controversies and discrepancies remain, the neurobiological role and the metabolic mechanisms of brain lactate have now been described. A theoretical framework on the relevance between lactate and brain function and brain diseases is presented. This review begins with the source and route of lactate formation in the brain and food; goes on to uncover the regulatory effect of lactate on brain function; and progresses to gathering the application and concentration variation of lactate in several brain diseases (diabetic encephalopathy, Alzheimer's disease, stroke, traumatic brain injury, and epilepsy) treatment. Finally, the dual role of lactate in the brain is discussed. This review highlights the biological effect of lactate, especially L-lactate, in brain function and disease studies and amplifies our understanding of past research. Frontiers Media S.A. 2022-04-28 /pmc/articles/PMC9099001/ /pubmed/35571940 http://dx.doi.org/10.3389/fnut.2022.800901 Text en Copyright © 2022 Cai, Wang, Song, Yang, Wang, Xue, Sun and Hu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Nutrition Cai, Ming Wang, Hongbiao Song, Haihan Yang, Ruoyu Wang, Liyan Xue, Xiangli Sun, Wanju Hu, Jingyun Lactate Is Answerable for Brain Function and Treating Brain Diseases: Energy Substrates and Signal Molecule |
title | Lactate Is Answerable for Brain Function and Treating Brain Diseases: Energy Substrates and Signal Molecule |
title_full | Lactate Is Answerable for Brain Function and Treating Brain Diseases: Energy Substrates and Signal Molecule |
title_fullStr | Lactate Is Answerable for Brain Function and Treating Brain Diseases: Energy Substrates and Signal Molecule |
title_full_unstemmed | Lactate Is Answerable for Brain Function and Treating Brain Diseases: Energy Substrates and Signal Molecule |
title_short | Lactate Is Answerable for Brain Function and Treating Brain Diseases: Energy Substrates and Signal Molecule |
title_sort | lactate is answerable for brain function and treating brain diseases: energy substrates and signal molecule |
topic | Nutrition |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099001/ https://www.ncbi.nlm.nih.gov/pubmed/35571940 http://dx.doi.org/10.3389/fnut.2022.800901 |
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