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Coronavirus Disease 2019 Vaccination During Pregnancy and Breastfeeding: A Review of Evidence and Current Recommendations in Europe, North America, and Australasia

In the late 2020s, less than 1 year into the coronavirus disease 2019 (COVID-19) pandemic, several anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines were introduced on a worldwide scale, with a significant positive impact on the consequences of the disease for several high-r...

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Autores principales: Pietrasanta, Carlo, Ronchi, Andrea, Crippa, Beatrice Letizia, Artieri, Giacomo, Ballerini, Claudia, Crimi, Riccardo, Mosca, Fabio, Pugni, Lorenza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099048/
https://www.ncbi.nlm.nih.gov/pubmed/35573944
http://dx.doi.org/10.3389/fped.2022.883953
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author Pietrasanta, Carlo
Ronchi, Andrea
Crippa, Beatrice Letizia
Artieri, Giacomo
Ballerini, Claudia
Crimi, Riccardo
Mosca, Fabio
Pugni, Lorenza
author_facet Pietrasanta, Carlo
Ronchi, Andrea
Crippa, Beatrice Letizia
Artieri, Giacomo
Ballerini, Claudia
Crimi, Riccardo
Mosca, Fabio
Pugni, Lorenza
author_sort Pietrasanta, Carlo
collection PubMed
description In the late 2020s, less than 1 year into the coronavirus disease 2019 (COVID-19) pandemic, several anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines were introduced on a worldwide scale, with a significant positive impact on the consequences of the disease for several high-risk population groups. In the case of most bacterial or viral respiratory infections, pregnant women are at increased risk of complications, however, neither pregnant nor breastfeeding women were included in the first round of randomized clinical trials evaluating the safety and effectiveness of COVID-19 vaccines, because of safety and ethical concerns. Nevertheless, most anti-SARS-CoV-2 vaccines have not been expressly contraindicated during pregnancy or breastfeeding, and observational data on immune response, adverse effects, and clinical efficacy in pregnant and breastfeeding women have been progressively gathered during 2021. The vast majority of these data is reassuring for what concerns side effects for women and infants and points out the efficacy of vaccines in protecting women against COVID-19-related complications. Despite this, the hesitancy of pregnant and breastfeeding women at being vaccinated is still real. In this mini-review, we resume the available data on the clinical consequences of COVID-19 in pregnant women, as well as adverse effects, systemic and mucosal immune response, and clinical effectiveness of COVID-19 vaccines in pregnant and breastfeeding women. Moreover, we offer an updated overview of European, North American, and Australasian recommendations concerning COVID-19 vaccination in pregnant and breastfeeding women, in order to safely ensure the highest protection of women and their infants.
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spelling pubmed-90990482022-05-14 Coronavirus Disease 2019 Vaccination During Pregnancy and Breastfeeding: A Review of Evidence and Current Recommendations in Europe, North America, and Australasia Pietrasanta, Carlo Ronchi, Andrea Crippa, Beatrice Letizia Artieri, Giacomo Ballerini, Claudia Crimi, Riccardo Mosca, Fabio Pugni, Lorenza Front Pediatr Pediatrics In the late 2020s, less than 1 year into the coronavirus disease 2019 (COVID-19) pandemic, several anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines were introduced on a worldwide scale, with a significant positive impact on the consequences of the disease for several high-risk population groups. In the case of most bacterial or viral respiratory infections, pregnant women are at increased risk of complications, however, neither pregnant nor breastfeeding women were included in the first round of randomized clinical trials evaluating the safety and effectiveness of COVID-19 vaccines, because of safety and ethical concerns. Nevertheless, most anti-SARS-CoV-2 vaccines have not been expressly contraindicated during pregnancy or breastfeeding, and observational data on immune response, adverse effects, and clinical efficacy in pregnant and breastfeeding women have been progressively gathered during 2021. The vast majority of these data is reassuring for what concerns side effects for women and infants and points out the efficacy of vaccines in protecting women against COVID-19-related complications. Despite this, the hesitancy of pregnant and breastfeeding women at being vaccinated is still real. In this mini-review, we resume the available data on the clinical consequences of COVID-19 in pregnant women, as well as adverse effects, systemic and mucosal immune response, and clinical effectiveness of COVID-19 vaccines in pregnant and breastfeeding women. Moreover, we offer an updated overview of European, North American, and Australasian recommendations concerning COVID-19 vaccination in pregnant and breastfeeding women, in order to safely ensure the highest protection of women and their infants. Frontiers Media S.A. 2022-04-29 /pmc/articles/PMC9099048/ /pubmed/35573944 http://dx.doi.org/10.3389/fped.2022.883953 Text en Copyright © 2022 Pietrasanta, Ronchi, Crippa, Artieri, Ballerini, Crimi, Mosca and Pugni. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Pietrasanta, Carlo
Ronchi, Andrea
Crippa, Beatrice Letizia
Artieri, Giacomo
Ballerini, Claudia
Crimi, Riccardo
Mosca, Fabio
Pugni, Lorenza
Coronavirus Disease 2019 Vaccination During Pregnancy and Breastfeeding: A Review of Evidence and Current Recommendations in Europe, North America, and Australasia
title Coronavirus Disease 2019 Vaccination During Pregnancy and Breastfeeding: A Review of Evidence and Current Recommendations in Europe, North America, and Australasia
title_full Coronavirus Disease 2019 Vaccination During Pregnancy and Breastfeeding: A Review of Evidence and Current Recommendations in Europe, North America, and Australasia
title_fullStr Coronavirus Disease 2019 Vaccination During Pregnancy and Breastfeeding: A Review of Evidence and Current Recommendations in Europe, North America, and Australasia
title_full_unstemmed Coronavirus Disease 2019 Vaccination During Pregnancy and Breastfeeding: A Review of Evidence and Current Recommendations in Europe, North America, and Australasia
title_short Coronavirus Disease 2019 Vaccination During Pregnancy and Breastfeeding: A Review of Evidence and Current Recommendations in Europe, North America, and Australasia
title_sort coronavirus disease 2019 vaccination during pregnancy and breastfeeding: a review of evidence and current recommendations in europe, north america, and australasia
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099048/
https://www.ncbi.nlm.nih.gov/pubmed/35573944
http://dx.doi.org/10.3389/fped.2022.883953
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