Hypoxic, glycolytic metabolism is a vulnerability of B-acute lymphoblastic leukemia-initiating cells

High-risk forms of B-acute lymphoblastic leukemia (B-ALL) remain a therapeutic challenge. Leukemia-initiating cells (LICs) self-renew and spark relapse and therefore have been the subject of intensive investigation; however, the properties of LICs in high-risk B-ALL are not well understood. Here, we...

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Detalles Bibliográficos
Autores principales: Morris, Vivian, Wang, Dahai, Li, Zhiheng, Marion, William, Hughes, Travis, Sousa, Patricia, Harada, Taku, Sui, Shannan Ho, Naumenko, Sergey, Kalfon, Jérémie, Sensharma, Prerana, Falchetti, Marcelo, da Silva, Renan Vinicius, Candelli, Tito, Schneider, Pauline, Margaritis, Thanasis, Holstege, Frank C.P., Pikman, Yana, Harris, Marian, Stam, Ronald W., Orkin, Stuart H., Koehler, Angela N., Shalek, Alex K., North, Trista E., Pimkin, Maxim, Daley, George Q., da Rocha, Edroaldo Lummertz, Rowe, R. Grant
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099058/
https://www.ncbi.nlm.nih.gov/pubmed/35476984
http://dx.doi.org/10.1016/j.celrep.2022.110752

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