New insights into IRE1α activation and function in anti-tumor immunity

Logue, Gorman, and Samali highlight a study by Guttman and colleagues (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202111068) that shows exogenous antigen peptides imported into the ER can activate the ER stress sensor IRE1α, attenuating cross-presentation by dendritic cells.

Detalles Bibliográficos
Autores principales: Logue, Susan E., Gorman, Adrienne M., Samali, Afshin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099116/
https://www.ncbi.nlm.nih.gov/pubmed/35544036
http://dx.doi.org/10.1083/jcb.202205019
Descripción
Sumario:Logue, Gorman, and Samali highlight a study by Guttman and colleagues (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202111068) that shows exogenous antigen peptides imported into the ER can activate the ER stress sensor IRE1α, attenuating cross-presentation by dendritic cells.

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