New insights into IRE1α activation and function in anti-tumor immunity

Logue, Gorman, and Samali highlight a study by Guttman and colleagues (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202111068) that shows exogenous antigen peptides imported into the ER can activate the ER stress sensor IRE1α, attenuating cross-presentation by dendritic cells.

Detalles Bibliográficos
Autores principales: Logue, Susan E., Gorman, Adrienne M., Samali, Afshin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099116/
https://www.ncbi.nlm.nih.gov/pubmed/35544036
http://dx.doi.org/10.1083/jcb.202205019
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author Logue, Susan E.
Gorman, Adrienne M.
Samali, Afshin
author_facet Logue, Susan E.
Gorman, Adrienne M.
Samali, Afshin
author_sort Logue, Susan E.
collection PubMed
description Logue, Gorman, and Samali highlight a study by Guttman and colleagues (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202111068) that shows exogenous antigen peptides imported into the ER can activate the ER stress sensor IRE1α, attenuating cross-presentation by dendritic cells.
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spelling pubmed-90991162022-12-06 New insights into IRE1α activation and function in anti-tumor immunity Logue, Susan E. Gorman, Adrienne M. Samali, Afshin J Cell Biol Spotlight Logue, Gorman, and Samali highlight a study by Guttman and colleagues (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202111068) that shows exogenous antigen peptides imported into the ER can activate the ER stress sensor IRE1α, attenuating cross-presentation by dendritic cells. Rockefeller University Press 2022-05-11 /pmc/articles/PMC9099116/ /pubmed/35544036 http://dx.doi.org/10.1083/jcb.202205019 Text en © 2022 Logue et al. https://creativecommons.org/licenses/by-nc-sa/4.0/http://www.rupress.org/terms/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Spotlight
Logue, Susan E.
Gorman, Adrienne M.
Samali, Afshin
New insights into IRE1α activation and function in anti-tumor immunity
title New insights into IRE1α activation and function in anti-tumor immunity
title_full New insights into IRE1α activation and function in anti-tumor immunity
title_fullStr New insights into IRE1α activation and function in anti-tumor immunity
title_full_unstemmed New insights into IRE1α activation and function in anti-tumor immunity
title_short New insights into IRE1α activation and function in anti-tumor immunity
title_sort new insights into ire1α activation and function in anti-tumor immunity
topic Spotlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099116/
https://www.ncbi.nlm.nih.gov/pubmed/35544036
http://dx.doi.org/10.1083/jcb.202205019
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