Phase I and scintigraphy studies to evaluate safety, tolerability, pharmacokinetics, and lung deposition of inhaled GDC‐0214 in healthy volunteers

Several inflammatory cytokines that promote inflammation and pathogenesis in asthma signal through the Janus kinase 1 (JAK1) pathway. This phase I, randomized, placebo‐controlled trial assessed the pharmacokinetics and safety of single and multiple ascending doses up to 15 mg twice daily for 14 days...

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Detalles Bibliográficos
Autores principales: Zhu, Rui, Chen, Hubert, Galanter, Joshua, She, Gaohong, Cai, Fang, Durk, Matthew R., Zou, Yixuan, Chen, Liuxi, Kenny, Jane R., Vadhavkar, Shweta, Warren, Simon, Taylor, Glyn, Hwang, Olivia, Eliahu, Avi, Wynne, Chris, Owen, Ryan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099118/
https://www.ncbi.nlm.nih.gov/pubmed/35157370
http://dx.doi.org/10.1111/cts.13240

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