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Albumin to globulin ratio was associated with in‐stent restenosis and revascularization events after percutaneous coronary intervention
In‐stent restenosis is a common complication after percutaneous coronary intervention (PCI) for coronary heart disease requiring revascularization. We performed a retrospective analysis to assess the value of inflammatory biomarker albumin to globulin ratio (AGR) in clinical prognosis of PCI. In tot...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099125/ https://www.ncbi.nlm.nih.gov/pubmed/35195938 http://dx.doi.org/10.1111/cts.13236 |
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author | Zhang, Rui Tao, Zaixiao Gong, Jing Ji, Zhenjun Yang, Mingming Ma, Genshan Li, Yongjun |
author_facet | Zhang, Rui Tao, Zaixiao Gong, Jing Ji, Zhenjun Yang, Mingming Ma, Genshan Li, Yongjun |
author_sort | Zhang, Rui |
collection | PubMed |
description | In‐stent restenosis is a common complication after percutaneous coronary intervention (PCI) for coronary heart disease requiring revascularization. We performed a retrospective analysis to assess the value of inflammatory biomarker albumin to globulin ratio (AGR) in clinical prognosis of PCI. In total, 992 patients with coronary heart disease who underwent the first drug‐eluting stent implantation and re‐examination angiography in our hospital were enrolled in this study. The AGR was measured. At mean follow‐up of 11.2 ± 4 months, the in‐stent restenosis (ISR) and revascularization events (including target lesion revascularization, target vessel revascularization, and revascularization of de novo lesions) occurred in 127 and 284 patients, respectively. Compared with the non‐ISR or non‐event group, AGR was significantly lower in the ISR group and the events group. Beyond that, albumin was significantly lower, whereas urea nitrogen, glucose, and Gensini score, as well as the proportions of a history of diabetes and peripheral vascular diseases were significantly higher in the ISR group and the events group. Age, heart rate, white blood cell, neutrophils, lymphocyte, monocyte, and incidence of ischemic stroke were significantly higher in the events group. Multivariate Cox regression analysis showed that AGR was independently associated with ISR (p = 0.032) and events (p = 0.024). Besides, Kaplan‐Meier analysis indicated that the higher quartile of AGR had a lower rate of ISR (p = 0.038) and events (p ≤ 0.001). Finally, the receiver operating characteristic curve for AGR in diagnosing ISR and events indicated that the area under the curve were 0.56 and 0.57, respectively. Therefore, AGR is one of the most important factors that independently associate with the ISR and revascularization events after PCI. |
format | Online Article Text |
id | pubmed-9099125 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90991252022-05-18 Albumin to globulin ratio was associated with in‐stent restenosis and revascularization events after percutaneous coronary intervention Zhang, Rui Tao, Zaixiao Gong, Jing Ji, Zhenjun Yang, Mingming Ma, Genshan Li, Yongjun Clin Transl Sci Research In‐stent restenosis is a common complication after percutaneous coronary intervention (PCI) for coronary heart disease requiring revascularization. We performed a retrospective analysis to assess the value of inflammatory biomarker albumin to globulin ratio (AGR) in clinical prognosis of PCI. In total, 992 patients with coronary heart disease who underwent the first drug‐eluting stent implantation and re‐examination angiography in our hospital were enrolled in this study. The AGR was measured. At mean follow‐up of 11.2 ± 4 months, the in‐stent restenosis (ISR) and revascularization events (including target lesion revascularization, target vessel revascularization, and revascularization of de novo lesions) occurred in 127 and 284 patients, respectively. Compared with the non‐ISR or non‐event group, AGR was significantly lower in the ISR group and the events group. Beyond that, albumin was significantly lower, whereas urea nitrogen, glucose, and Gensini score, as well as the proportions of a history of diabetes and peripheral vascular diseases were significantly higher in the ISR group and the events group. Age, heart rate, white blood cell, neutrophils, lymphocyte, monocyte, and incidence of ischemic stroke were significantly higher in the events group. Multivariate Cox regression analysis showed that AGR was independently associated with ISR (p = 0.032) and events (p = 0.024). Besides, Kaplan‐Meier analysis indicated that the higher quartile of AGR had a lower rate of ISR (p = 0.038) and events (p ≤ 0.001). Finally, the receiver operating characteristic curve for AGR in diagnosing ISR and events indicated that the area under the curve were 0.56 and 0.57, respectively. Therefore, AGR is one of the most important factors that independently associate with the ISR and revascularization events after PCI. John Wiley and Sons Inc. 2022-02-27 2022-05 /pmc/articles/PMC9099125/ /pubmed/35195938 http://dx.doi.org/10.1111/cts.13236 Text en © 2022 The Authors. Clinical and Translational Science published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Research Zhang, Rui Tao, Zaixiao Gong, Jing Ji, Zhenjun Yang, Mingming Ma, Genshan Li, Yongjun Albumin to globulin ratio was associated with in‐stent restenosis and revascularization events after percutaneous coronary intervention |
title | Albumin to globulin ratio was associated with in‐stent restenosis and revascularization events after percutaneous coronary intervention |
title_full | Albumin to globulin ratio was associated with in‐stent restenosis and revascularization events after percutaneous coronary intervention |
title_fullStr | Albumin to globulin ratio was associated with in‐stent restenosis and revascularization events after percutaneous coronary intervention |
title_full_unstemmed | Albumin to globulin ratio was associated with in‐stent restenosis and revascularization events after percutaneous coronary intervention |
title_short | Albumin to globulin ratio was associated with in‐stent restenosis and revascularization events after percutaneous coronary intervention |
title_sort | albumin to globulin ratio was associated with in‐stent restenosis and revascularization events after percutaneous coronary intervention |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099125/ https://www.ncbi.nlm.nih.gov/pubmed/35195938 http://dx.doi.org/10.1111/cts.13236 |
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