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Albumin to globulin ratio was associated with in‐stent restenosis and revascularization events after percutaneous coronary intervention

In‐stent restenosis is a common complication after percutaneous coronary intervention (PCI) for coronary heart disease requiring revascularization. We performed a retrospective analysis to assess the value of inflammatory biomarker albumin to globulin ratio (AGR) in clinical prognosis of PCI. In tot...

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Autores principales: Zhang, Rui, Tao, Zaixiao, Gong, Jing, Ji, Zhenjun, Yang, Mingming, Ma, Genshan, Li, Yongjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099125/
https://www.ncbi.nlm.nih.gov/pubmed/35195938
http://dx.doi.org/10.1111/cts.13236
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author Zhang, Rui
Tao, Zaixiao
Gong, Jing
Ji, Zhenjun
Yang, Mingming
Ma, Genshan
Li, Yongjun
author_facet Zhang, Rui
Tao, Zaixiao
Gong, Jing
Ji, Zhenjun
Yang, Mingming
Ma, Genshan
Li, Yongjun
author_sort Zhang, Rui
collection PubMed
description In‐stent restenosis is a common complication after percutaneous coronary intervention (PCI) for coronary heart disease requiring revascularization. We performed a retrospective analysis to assess the value of inflammatory biomarker albumin to globulin ratio (AGR) in clinical prognosis of PCI. In total, 992 patients with coronary heart disease who underwent the first drug‐eluting stent implantation and re‐examination angiography in our hospital were enrolled in this study. The AGR was measured. At mean follow‐up of 11.2 ± 4 months, the in‐stent restenosis (ISR) and revascularization events (including target lesion revascularization, target vessel revascularization, and revascularization of de novo lesions) occurred in 127 and 284 patients, respectively. Compared with the non‐ISR or non‐event group, AGR was significantly lower in the ISR group and the events group. Beyond that, albumin was significantly lower, whereas urea nitrogen, glucose, and Gensini score, as well as the proportions of a history of diabetes and peripheral vascular diseases were significantly higher in the ISR group and the events group. Age, heart rate, white blood cell, neutrophils, lymphocyte, monocyte, and incidence of ischemic stroke were significantly higher in the events group. Multivariate Cox regression analysis showed that AGR was independently associated with ISR (p = 0.032) and events (p = 0.024). Besides, Kaplan‐Meier analysis indicated that the higher quartile of AGR had a lower rate of ISR (p = 0.038) and events (p ≤ 0.001). Finally, the receiver operating characteristic curve for AGR in diagnosing ISR and events indicated that the area under the curve were 0.56 and 0.57, respectively. Therefore, AGR is one of the most important factors that independently associate with the ISR and revascularization events after PCI.
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spelling pubmed-90991252022-05-18 Albumin to globulin ratio was associated with in‐stent restenosis and revascularization events after percutaneous coronary intervention Zhang, Rui Tao, Zaixiao Gong, Jing Ji, Zhenjun Yang, Mingming Ma, Genshan Li, Yongjun Clin Transl Sci Research In‐stent restenosis is a common complication after percutaneous coronary intervention (PCI) for coronary heart disease requiring revascularization. We performed a retrospective analysis to assess the value of inflammatory biomarker albumin to globulin ratio (AGR) in clinical prognosis of PCI. In total, 992 patients with coronary heart disease who underwent the first drug‐eluting stent implantation and re‐examination angiography in our hospital were enrolled in this study. The AGR was measured. At mean follow‐up of 11.2 ± 4 months, the in‐stent restenosis (ISR) and revascularization events (including target lesion revascularization, target vessel revascularization, and revascularization of de novo lesions) occurred in 127 and 284 patients, respectively. Compared with the non‐ISR or non‐event group, AGR was significantly lower in the ISR group and the events group. Beyond that, albumin was significantly lower, whereas urea nitrogen, glucose, and Gensini score, as well as the proportions of a history of diabetes and peripheral vascular diseases were significantly higher in the ISR group and the events group. Age, heart rate, white blood cell, neutrophils, lymphocyte, monocyte, and incidence of ischemic stroke were significantly higher in the events group. Multivariate Cox regression analysis showed that AGR was independently associated with ISR (p = 0.032) and events (p = 0.024). Besides, Kaplan‐Meier analysis indicated that the higher quartile of AGR had a lower rate of ISR (p = 0.038) and events (p ≤ 0.001). Finally, the receiver operating characteristic curve for AGR in diagnosing ISR and events indicated that the area under the curve were 0.56 and 0.57, respectively. Therefore, AGR is one of the most important factors that independently associate with the ISR and revascularization events after PCI. John Wiley and Sons Inc. 2022-02-27 2022-05 /pmc/articles/PMC9099125/ /pubmed/35195938 http://dx.doi.org/10.1111/cts.13236 Text en © 2022 The Authors. Clinical and Translational Science published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research
Zhang, Rui
Tao, Zaixiao
Gong, Jing
Ji, Zhenjun
Yang, Mingming
Ma, Genshan
Li, Yongjun
Albumin to globulin ratio was associated with in‐stent restenosis and revascularization events after percutaneous coronary intervention
title Albumin to globulin ratio was associated with in‐stent restenosis and revascularization events after percutaneous coronary intervention
title_full Albumin to globulin ratio was associated with in‐stent restenosis and revascularization events after percutaneous coronary intervention
title_fullStr Albumin to globulin ratio was associated with in‐stent restenosis and revascularization events after percutaneous coronary intervention
title_full_unstemmed Albumin to globulin ratio was associated with in‐stent restenosis and revascularization events after percutaneous coronary intervention
title_short Albumin to globulin ratio was associated with in‐stent restenosis and revascularization events after percutaneous coronary intervention
title_sort albumin to globulin ratio was associated with in‐stent restenosis and revascularization events after percutaneous coronary intervention
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099125/
https://www.ncbi.nlm.nih.gov/pubmed/35195938
http://dx.doi.org/10.1111/cts.13236
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