Cargando…

Elevation of fatty acid desaturase 2 in esophageal adenocarcinoma increases polyunsaturated lipids and may exacerbate bile acid‐induced DNA damage

BACKGROUND: The risk of esophageal adenocarcinoma (EAC) is associated with gastro‐esophageal reflux disease (GERD) and obesity. Lipid metabolism‐targeted therapies decrease the risk of progressing from Barrett's esophagus (BE) to EAC, but the precise lipid metabolic changes and their roles in g...

Descripción completa

Detalles Bibliográficos
Autores principales:	Molendijk, Jeffrey, Kolka, Cathryn M., Cairns, Henry, Brosda, Sandra, Mohamed, Ahmed, Shah, Alok K., Brown, Ian, Hodson, Mark P., Hennessy, Thomas, Liu, Guanghao, Stoll, Thomas, Richards, Renee S., Gartside, Michael, Patel, Kalpana, Clemons, Nicholas J., Phillips, Wayne A., Barbour, Andrew, Westerhuis, Johan A., Hill, Michelle M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099135/ https://www.ncbi.nlm.nih.gov/pubmed/35560527 http://dx.doi.org/10.1002/ctm2.810

Ejemplares similares

Fatty Acid Desaturases, Polyunsaturated Fatty Acid Regulation, and Biotechnological Advances
por: Lee, Je Min, et al.
Publicado: (2016)

Δ12-Fatty Acid Desaturase from Candida parapsilosis Is a Multifunctional Desaturase Producing a Range of Polyunsaturated and Hydroxylated Fatty Acids
por: Buček, Aleš, et al.
Publicado: (2014)

Comparison of the Substrate Preferences of ω3 Fatty Acid Desaturases for Long Chain Polyunsaturated Fatty Acids
por: Shrestha, Pushkar, et al.
Publicado: (2019)

The association of fatty acid desaturase gene polymorphisms on long-chain polyunsaturated fatty acid composition in Indonesian infants
por: Tanjung, Conny, et al.
Publicado: (2018)

Altered polyunsaturated fatty acid levels in relation to proinflammatory cytokines, fatty acid desaturase genotype, and diet in bipolar disorder
por: Koga, Norie, et al.
Publicado: (2019)

N-3 Polyunsaturated Fatty Acids Stimulate Bile Acid Detoxification in Human Cell Models
por: Cieślak, Anna, et al.
Publicado: (2018)

Polymorphisms in Fatty Acid Desaturase (FADS) Gene Cluster: Effects on Glycemic Controls Following an Omega-3 Polyunsaturated Fatty Acids (PUFA) Supplementation
por: Cormier, Hubert, et al.
Publicado: (2013)

Dietary n-3 Polyunsaturated Fatty Acid Intakes Modify the Effect of Genetic Variation in Fatty Acid Desaturase 1 on Coronary Artery Disease
por: Liu, Fengqiong, et al.
Publicado: (2015)

Association of Fatty Acid Desaturase 1 rs174547 Polymorphism with the Composition of Long-Chain Polyunsaturated Fatty Acids in Serum Glycerophospholipids during Pregnancy
por: Kawabata, Terue, et al.
Publicado: (2023)

Omega-3 Polyunsaturated Fatty Acid for Cholestasis due to Bile Duct Paucity
por: Bae, Sun Hwan, et al.
Publicado: (2014)

Insulin access to skeletal muscle is preserved in obesity induced by polyunsaturated diet
por: Broussard, Josiane L., et al.
Publicado: (2017)

C5b-9 Membrane Attack Complex Formation and Extracellular Vesicle Shedding in Barrett’s Esophagus and Esophageal Adenocarcinoma
por: Kolka, Cathryn M., et al.
Publicado: (2022)

Transgenic expression of delta-6 and delta-15 fatty acid desaturases enhances omega-3 polyunsaturated fatty acid accumulation in Synechocystis sp. PCC6803
por: Chen, Gao, et al.
Publicado: (2014)

Menhaden oil, but not safflower or soybean oil, aids in restoring the polyunsaturated fatty acid profile in the novel delta-6-desaturase null mouse
por: Monteiro, Jessica, et al.
Publicado: (2012)

Fatty acid desaturase (FADS) gene polymorphisms and insulin resistance in association with serum phospholipid polyunsaturated fatty acid composition in healthy Korean men: cross-sectional study
por: Kim, Oh Yoen, et al.
Publicado: (2011)

Long-Chain Polyunsaturated Fatty Acids, Homocysteine at Birth and Fatty Acid Desaturase Gene Cluster Polymorphisms Are Associated with Children’s Processing Speed up to Age 9 Years
por: Campoy, Cristina, et al.
Publicado: (2020)

Identification of bile acid-CoA:amino acid N-acyltransferase as the hepatic N-acyl taurine synthase for polyunsaturated fatty acids
por: Trammell, Samuel A.J., et al.
Publicado: (2023)

The role of fatty acid desaturases in epidermal metabolism
por: Sampath, Harini, et al.
Publicado: (2011)

A More Desirable Balanced Polyunsaturated Fatty Acid Composition Achieved by Heterologous Expression of Δ15/Δ4 Desaturases in Mammalian Cells
por: Zhu, Guiming, et al.
Publicado: (2013)

Biosynthesis of Polyunsaturated Fatty Acids in Sea Urchins: Molecular and Functional Characterisation of Three Fatty Acyl Desaturases from Paracentrotus lividus (Lamark 1816)
por: Kabeya, Naoki, et al.
Publicado: (2017)

MicroRNA-193a-5p Regulates the Synthesis of Polyunsaturated Fatty Acids by Targeting Fatty Acid Desaturase 1 (FADS1) in Bovine Mammary Epithelial Cells
por: Fan, Yongliang, et al.
Publicado: (2021)

Postprandial effects of a meal low in sulfur amino acids and high in polyunsaturated fatty acids compared to a meal high in sulfur amino acids and saturated fatty acids on stearoyl CoA-desaturase indices and plasma sulfur amino acids: a pilot study
por: Olsen, Thomas, et al.
Publicado: (2020)

Kinetics of Saturated, Monounsaturated, and Polyunsaturated Fatty Acids in Humans
por: Nelson, Robert H., et al.
Publicado: (2013)

The effect of ω-3 polyunsaturated fatty acids on the liver lipidome, proteome and bile acid profile: parenteral versus enteral administration
por: Bechynska, Kamila, et al.
Publicado: (2019)

Classification and substrate head-group specificity of membrane fatty acid desaturases
por: Li, Dongdi, et al.
Publicado: (2016)

Use of Omega-3 Polyunsaturated Fatty Acids to Treat Inspissated Bile Syndrome: A Case Report
por: Jun, Woo Young, et al.
Publicado: (2016)

The codon-optimized Δ(6)-desaturase gene of Pythium sp. as an empowering tool for engineering n3/n6 polyunsaturated fatty acid biosynthesis
por: Jeennor, Sukanya, et al.
Publicado: (2015)

Biosynthesis of Polyunsaturated Fatty Acids in Octopus vulgaris: Molecular Cloning and Functional Characterisation of a Stearoyl-CoA Desaturase and an Elongation of Very Long-Chain Fatty Acid 4 Protein
por: Monroig, Óscar, et al.
Publicado: (2017)

Comparative Analysis of Fatty Acid Desaturases in Cyanobacterial Genomes
por: Chi, Xiaoyuan, et al.
Publicado: (2008)

Expression and Purification of Integral Membrane Fatty Acid Desaturases
por: Chen, Haiqin, et al.
Publicado: (2013)

A novel Tetrahymena thermophila sterol C-22 desaturase belongs to the fatty acid hydroxylase/desaturase superfamily
por: Sanchez Granel, María L., et al.
Publicado: (2022)

High fat / high cholesterol diet does not provoke atherosclerosis in the ω3-and ω6-polyunsaturated fatty acid synthesis–inactivated Δ6-fatty acid desaturase–deficient mouse
por: Stoffel, Wilhelm, et al.
Publicado: (2021)

Polyunsaturated Fatty Acids in Children
por: Lee, Ji-Hyuk
Publicado: (2013)

Retention of fatty acyl desaturase 1 (fads1) in Elopomorpha and Cyclostomata provides novel insights into the evolution of long-chain polyunsaturated fatty acid biosynthesis in vertebrates
por: Lopes-Marques, Mónica, et al.
Publicado: (2018)

Polyunsaturated Fatty Acids and Their Immunomodulatory Actions in Periodontal Disease
por: Panezai, Jeneen, et al.
Publicado: (2023)

Increased hydrophilic plasma bile acids are correlated with protection from adiposity in skin-specific stearoyl-CoA desaturase-1 deficient mice
por: Dumas, Sabrina N., et al.
Publicado: (2018)

Identification and characterization of new Δ-17 fatty acid desaturases
por: Xue, Zhixiong, et al.
Publicado: (2012)

Inventory of Fatty Acid Desaturases in the Pennate Diatom Phaeodactylum tricornutum
por: Dolch, Lina-Juana, et al.
Publicado: (2015)

Selection in Europeans on Fatty Acid Desaturases Associated with Dietary Changes
por: Buckley, Matthew T., et al.
Publicado: (2017)

Biological Role of Unsaturated Fatty Acid Desaturases in Health and Disease
por: Czumaj, Aleksandra, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_opcskgauvhnb0bahg3h5vcqq6i