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NSUN2 Promotes Tumor Progression and Regulates Immune Infiltration in Nasopharyngeal Carcinoma

Nasopharyngeal carcinoma (NPC) is one of the most common malignancies in the head and neck with a complex etiology, such as environmental factors, genetic factors, and Epstein–Barr virus infection. The NOP2/Sun domain family, member 2 (NSUN2) is a methyltransferase of m5C methylation modification th...

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Autores principales: Tong, Xinya, Xiang, Yilan, Hu, Yuanbo, Hu, Yingying, Li, He, Wang, Huilin, Zhao, Kong-Nan, Xue, Xiangyang, Zhu, Shanli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099203/
https://www.ncbi.nlm.nih.gov/pubmed/35574373
http://dx.doi.org/10.3389/fonc.2022.788801
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author Tong, Xinya
Xiang, Yilan
Hu, Yuanbo
Hu, Yingying
Li, He
Wang, Huilin
Zhao, Kong-Nan
Xue, Xiangyang
Zhu, Shanli
author_facet Tong, Xinya
Xiang, Yilan
Hu, Yuanbo
Hu, Yingying
Li, He
Wang, Huilin
Zhao, Kong-Nan
Xue, Xiangyang
Zhu, Shanli
author_sort Tong, Xinya
collection PubMed
description Nasopharyngeal carcinoma (NPC) is one of the most common malignancies in the head and neck with a complex etiology, such as environmental factors, genetic factors, and Epstein–Barr virus infection. The NOP2/Sun domain family, member 2 (NSUN2) is a methyltransferase of m5C methylation modification that has been reported to be involved in the occurrence and progression of various tumors, but its role in NPC remains unclear. In this study, we found that NSUN2 was upregulated in NPC and predicted a poor prognosis for NPC patients in both GEO datasets and our tissue microarrays containing 125 NPC tissues. Next, we demonstrated that NSUN2 promoted the proliferation, migration, and invasion of NPC cells in vitro. Additionally, the differential expression genes between NSUN2-high and low expression patients were mainly enriched in multi-immune cell activation and proliferation. Furthermore, NSUN2 negatively regulates immune cell infiltration in the tumor microenvironment (TME) of NPC, which indicates that the NSUN2 level may be negatively correlated with the sensitivity of immunotherapy and chemotherapy. In conclusion, our findings highlight that NSUN2 might act as an important oncogene involved in NPC progression and serve as a potential biomarker to predict poor prognosis and drug sensitivity of NPC patients.
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spelling pubmed-90992032022-05-14 NSUN2 Promotes Tumor Progression and Regulates Immune Infiltration in Nasopharyngeal Carcinoma Tong, Xinya Xiang, Yilan Hu, Yuanbo Hu, Yingying Li, He Wang, Huilin Zhao, Kong-Nan Xue, Xiangyang Zhu, Shanli Front Oncol Oncology Nasopharyngeal carcinoma (NPC) is one of the most common malignancies in the head and neck with a complex etiology, such as environmental factors, genetic factors, and Epstein–Barr virus infection. The NOP2/Sun domain family, member 2 (NSUN2) is a methyltransferase of m5C methylation modification that has been reported to be involved in the occurrence and progression of various tumors, but its role in NPC remains unclear. In this study, we found that NSUN2 was upregulated in NPC and predicted a poor prognosis for NPC patients in both GEO datasets and our tissue microarrays containing 125 NPC tissues. Next, we demonstrated that NSUN2 promoted the proliferation, migration, and invasion of NPC cells in vitro. Additionally, the differential expression genes between NSUN2-high and low expression patients were mainly enriched in multi-immune cell activation and proliferation. Furthermore, NSUN2 negatively regulates immune cell infiltration in the tumor microenvironment (TME) of NPC, which indicates that the NSUN2 level may be negatively correlated with the sensitivity of immunotherapy and chemotherapy. In conclusion, our findings highlight that NSUN2 might act as an important oncogene involved in NPC progression and serve as a potential biomarker to predict poor prognosis and drug sensitivity of NPC patients. Frontiers Media S.A. 2022-04-29 /pmc/articles/PMC9099203/ /pubmed/35574373 http://dx.doi.org/10.3389/fonc.2022.788801 Text en Copyright © 2022 Tong, Xiang, Hu, Hu, Li, Wang, Zhao, Xue and Zhu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Tong, Xinya
Xiang, Yilan
Hu, Yuanbo
Hu, Yingying
Li, He
Wang, Huilin
Zhao, Kong-Nan
Xue, Xiangyang
Zhu, Shanli
NSUN2 Promotes Tumor Progression and Regulates Immune Infiltration in Nasopharyngeal Carcinoma
title NSUN2 Promotes Tumor Progression and Regulates Immune Infiltration in Nasopharyngeal Carcinoma
title_full NSUN2 Promotes Tumor Progression and Regulates Immune Infiltration in Nasopharyngeal Carcinoma
title_fullStr NSUN2 Promotes Tumor Progression and Regulates Immune Infiltration in Nasopharyngeal Carcinoma
title_full_unstemmed NSUN2 Promotes Tumor Progression and Regulates Immune Infiltration in Nasopharyngeal Carcinoma
title_short NSUN2 Promotes Tumor Progression and Regulates Immune Infiltration in Nasopharyngeal Carcinoma
title_sort nsun2 promotes tumor progression and regulates immune infiltration in nasopharyngeal carcinoma
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099203/
https://www.ncbi.nlm.nih.gov/pubmed/35574373
http://dx.doi.org/10.3389/fonc.2022.788801
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