Cargando…

Brain-Specific Increase in Leukotriene Signaling Accompanies Chronic Neuroinflammation and Cognitive Impairment in a Model of Gulf War Illness

Persistent cognitive impairment is a primary central nervous system-related symptom in veterans afflicted with chronic Gulf War Illness (GWI). Previous studies in a rat model have revealed that cognitive dysfunction in chronic GWI is associated with neuroinflammation, typified by astrocyte hypertrop...

Descripción completa

Detalles Bibliográficos
Autores principales:	Attaluri, Sahithi, Upadhya, Raghavendra, Kodali, Maheedhar, Madhu, Leelavathi N., Upadhya, Dinesh, Shuai, Bing, Shetty, Ashok K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099214/ https://www.ncbi.nlm.nih.gov/pubmed/35572589 http://dx.doi.org/10.3389/fimmu.2022.853000

Ejemplares similares

Monosodium luminol reinstates redox homeostasis, improves cognition, mood and neurogenesis, and alleviates neuro- and systemic inflammation in a model of Gulf War Illness
por: Shetty, Ashok K., et al.
Publicado: (2019)

Chronic Oxidative Stress, Mitochondrial Dysfunction, Nrf2 Activation and Inflammation in the Hippocampus Accompany Heightened Systemic Inflammation and Oxidative Stress in an Animal Model of Gulf War Illness
por: Shetty, Geetha A., et al.
Publicado: (2017)

Oral Nano-Curcumin in a Model of Chronic Gulf War Illness Alleviates Brain Dysfunction with Modulation of Oxidative Stress, Mitochondrial Function, Neuroinflammation, Neurogenesis, and Gene Expression
por: Attaluri, Sahithi, et al.
Publicado: (2022)

Melatonin improves brain function in a model of chronic Gulf War Illness with modulation of oxidative stress, NLRP3 inflammasomes, and BDNF-ERK-CREB pathway in the hippocampus
por: Madhu, Leelavathi N., et al.
Publicado: (2021)

Metformin treatment in late middle age improves cognitive function with alleviation of microglial activation and enhancement of autophagy in the hippocampus
por: Kodali, Maheedhar, et al.
Publicado: (2021)

A single intranasal dose of human mesenchymal stem cell-derived extracellular vesicles after traumatic brain injury eases neurogenesis decline, synapse loss, and BDNF-ERK-CREB signaling
por: Kodali, Maheedhar, et al.
Publicado: (2023)

Novel Insights on Systemic and Brain Aging, Stroke, Amyotrophic Lateral Sclerosis, and Alzheimer’s Disease
por: Shetty, Ashok K., et al.
Publicado: (2019)

Emerging Anti-Aging Strategies - Scientific Basis and Efficacy
por: Shetty, Ashok K., et al.
Publicado: (2018)

A Model of Chronic Temporal Lobe Epilepsy Presenting Constantly Rhythmic and Robust Spontaneous Seizures, Co-morbidities and Hippocampal Neuropathology
por: Upadhya, Dinesh, et al.
Publicado: (2019)

Intranasally Administered Human MSC-Derived Extracellular Vesicles Pervasively Incorporate into Neurons and Microglia in both Intact and Status Epilepticus Injured Forebrain
por: Kodali, Maheedhar, et al.
Publicado: (2019)

Extracellular vesicles from human iPSC-derived neural stem cells: miRNA and protein signatures, and anti-inflammatory and neurogenic properties
por: Upadhya, Raghavendra, et al.
Publicado: (2020)

Intranasally administered extracellular vesicles from human induced pluripotent stem cell-derived neural stem cells quickly incorporate into neurons and microglia in 5xFAD mice
por: Attaluri, Sahithi, et al.
Publicado: (2023)

Object location and object recognition memory impairments, motivation deficits and depression in a model of Gulf War illness
por: Hattiangady, Bharathi, et al.
Publicado: (2014)

Human induced pluripotent stem cell-derived MGE cell grafting after status epilepticus attenuates chronic epilepsy and comorbidities via synaptic integration
por: Upadhya, Dinesh, et al.
Publicado: (2019)

Resveratrol for Easing Status Epilepticus Induced Brain Injury, Inflammation, Epileptogenesis, and Cognitive and Memory Dysfunction—Are We There Yet?
por: Castro, Olagide W., et al.
Publicado: (2017)

Proficiency of Extracellular Vesicles From hiPSC-Derived Neural Stem Cells in Modulating Proinflammatory Human Microglia: Role of Pentraxin-3 and miRNA-21-5p
por: Upadhya, Raghavendra, et al.
Publicado: (2022)

Promise of metformin for preventing age-related cognitive dysfunction
por: Madhu, Leelavathi N., et al.
Publicado: (2021)

Grafted hPSC-derived GABA-ergic interneurons regulate seizures and specific cognitive function in temporal lobe epilepsy
por: Upadhya, Dinesh, et al.
Publicado: (2022)

Gulf war illness-related chemicals increase CD11b/c(+) monocyte infiltration into the liver and aggravate hepatic cholestasis in a rodent model
por: Petrescu, Anca D., et al.
Publicado: (2018)

Extracellular Vesicles in Health and Disease
por: Shetty, Ashok K, et al.
Publicado: (2021)

Extracellular Vesicles for the Diagnosis and Treatment of Parkinson’s Disease
por: Upadhya, Raghavendra, et al.
Publicado: (2021)

Parvalbumin and neuropeptide Y expressing hippocampal GABA-ergic inhibitory interneuron numbers decline in a model of Gulf War illness
por: Megahed, Tarick, et al.
Publicado: (2015)

Grappling with Gulf War Illness: Perspectives of Gulf War Providers
por: Kaimal, Girija, et al.
Publicado: (2020)

Update on Gulf War illness.
Publicado: (1997)

Neural stem cell derived extracellular vesicles: Attributes and prospects for treating neurodegenerative disorders
por: Vogel, Andrew D., et al.
Publicado: (2018)

Dysbiosis in gastrointestinal pathophysiology: Role of the gut microbiome in Gulf War Illness
por: Slevin, Elise, et al.
Publicado: (2023)

Metabolic features of Gulf War illness
por: Naviaux, Robert K., et al.
Publicado: (2019)

Oligodendrocyte involvement in Gulf War Illness
por: Belgrad, Jillian, et al.
Publicado: (2019)

The Department of Veterans Affairs Gulf War Veterans’ Illnesses Biorepository: Supporting Research on Gulf War Veterans’ Illnesses
por: Brady, Christopher B., et al.
Publicado: (2021)

Associations of Immune Genetic Variability with Gulf War Illness in 1990–1991 Gulf War Veterans from the Gulf War Illness Consortium (GWIC) Multisite Case-Control Study
por: Coller, Janet K., et al.
Publicado: (2021)

Impaired immune function in Gulf War Illness
por: Whistler, Toni, et al.
Publicado: (2009)

A Neuroimmune Model of Gulf War Illness
por: Coughlin, Steven S.
Publicado: (2017)

Brain–Immune Interactions as the Basis of Gulf War Illness: Clinical Assessment and Deployment Profile of 1990–1991 Gulf War Veterans in the Gulf War Illness Consortium (GWIC) Multisite Case-Control Study
por: Steele, Lea, et al.
Publicado: (2021)

Towards a Biopsychosocial Model of Gulf War Illness?
por: Wojcik, Wojtek, et al.
Publicado: (2015)

Blood Biomarkers of Chronic Inflammation in Gulf War Illness
por: Johnson, Gerhard J., et al.
Publicado: (2016)

Supporting a Neuroimmune Basis of Gulf War Illness
por: O'Callaghan, James P., et al.
Publicado: (2016)

Neuropsychological Findings in Gulf War Illness: A Review
por: Jeffrey, Mary G., et al.
Publicado: (2019)

Progression of intervention-focused research for Gulf War illness
por: Chester, Jeremy E., et al.
Publicado: (2019)

Transcranial Photobiomodulation to Improve Cognition in Gulf War Illness
por: Martin, Paula I., et al.
Publicado: (2021)

Resveratrol Prevents Age-Related Memory and Mood Dysfunction with Increased Hippocampal Neurogenesis and Microvasculature, and Reduced Glial Activation
por: Kodali, Maheedhar, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_mj1i0elu20bd88kdt1cin9cd6l