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Case Report: The Application of Dupilumab in Atopic Dermatitis Children Complicated With Nephrotic Syndrome
Nephrotic syndrome (NS) tends to be more common in patients with history of allergies. Atopic dermatitis (AD) is one of the most common allergic diseases in children. Dupilumab, a dual IL-4 and IL-13 inhibitor, has been widely used to treat AD patients. However, the efficacy and safety of Dupilumab...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099359/ https://www.ncbi.nlm.nih.gov/pubmed/35573014 http://dx.doi.org/10.3389/fmed.2022.813313 |
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author | Yang, Ya-Qi Chen, Hao Qiu, Li-Ru Zhu, Rong-Fei |
author_facet | Yang, Ya-Qi Chen, Hao Qiu, Li-Ru Zhu, Rong-Fei |
author_sort | Yang, Ya-Qi |
collection | PubMed |
description | Nephrotic syndrome (NS) tends to be more common in patients with history of allergies. Atopic dermatitis (AD) is one of the most common allergic diseases in children. Dupilumab, a dual IL-4 and IL-13 inhibitor, has been widely used to treat AD patients. However, the efficacy and safety of Dupilumab in NS is unclear. We reported two AD patients with NS comorbidities treated with Dupilumab. The outcomes showed the good control of NS and less systemic steroids and/or immunosuppressive agents use during the Dupilumab treatment period, accompanied by significant relief of AD symptoms. We suggest prospective pilot studies and randomized controlled trials could be carried out to validate the efficacy and safety of Dupilumab in the treatment of NS patients. |
format | Online Article Text |
id | pubmed-9099359 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90993592022-05-14 Case Report: The Application of Dupilumab in Atopic Dermatitis Children Complicated With Nephrotic Syndrome Yang, Ya-Qi Chen, Hao Qiu, Li-Ru Zhu, Rong-Fei Front Med (Lausanne) Medicine Nephrotic syndrome (NS) tends to be more common in patients with history of allergies. Atopic dermatitis (AD) is one of the most common allergic diseases in children. Dupilumab, a dual IL-4 and IL-13 inhibitor, has been widely used to treat AD patients. However, the efficacy and safety of Dupilumab in NS is unclear. We reported two AD patients with NS comorbidities treated with Dupilumab. The outcomes showed the good control of NS and less systemic steroids and/or immunosuppressive agents use during the Dupilumab treatment period, accompanied by significant relief of AD symptoms. We suggest prospective pilot studies and randomized controlled trials could be carried out to validate the efficacy and safety of Dupilumab in the treatment of NS patients. Frontiers Media S.A. 2022-04-29 /pmc/articles/PMC9099359/ /pubmed/35573014 http://dx.doi.org/10.3389/fmed.2022.813313 Text en Copyright © 2022 Yang, Chen, Qiu and Zhu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Yang, Ya-Qi Chen, Hao Qiu, Li-Ru Zhu, Rong-Fei Case Report: The Application of Dupilumab in Atopic Dermatitis Children Complicated With Nephrotic Syndrome |
title | Case Report: The Application of Dupilumab in Atopic Dermatitis Children Complicated With Nephrotic Syndrome |
title_full | Case Report: The Application of Dupilumab in Atopic Dermatitis Children Complicated With Nephrotic Syndrome |
title_fullStr | Case Report: The Application of Dupilumab in Atopic Dermatitis Children Complicated With Nephrotic Syndrome |
title_full_unstemmed | Case Report: The Application of Dupilumab in Atopic Dermatitis Children Complicated With Nephrotic Syndrome |
title_short | Case Report: The Application of Dupilumab in Atopic Dermatitis Children Complicated With Nephrotic Syndrome |
title_sort | case report: the application of dupilumab in atopic dermatitis children complicated with nephrotic syndrome |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099359/ https://www.ncbi.nlm.nih.gov/pubmed/35573014 http://dx.doi.org/10.3389/fmed.2022.813313 |
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