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The Incidence and Risk Factors for Metachronous Gastric Cancer in the Remnant Stomach after Gastric Cancer Surgery
BACKGROUND/AIMS: Less invasive surgical treatment is performed in East Asia to preserve postoperative digestive function and reduce complications such as postgastrectomy syndromes, but there is an issue of metachronous gastric cancer (GC) in the remaining stomach. This study aimed to analyze the inc...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Editorial Office of Gut and Liver
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099384/ https://www.ncbi.nlm.nih.gov/pubmed/34462394 http://dx.doi.org/10.5009/gnl210202 |
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author | Choi, Yonghoon Kim, Nayoung Yoon, Hyuk Shin, Cheol Min Park, Young Soo Lee, Dong Ho Park, Young Suk Ahn, Sang-Hoon Suh, Yun-Suhk Park, Do Joong Kim, Hyung Ho |
author_facet | Choi, Yonghoon Kim, Nayoung Yoon, Hyuk Shin, Cheol Min Park, Young Soo Lee, Dong Ho Park, Young Suk Ahn, Sang-Hoon Suh, Yun-Suhk Park, Do Joong Kim, Hyung Ho |
author_sort | Choi, Yonghoon |
collection | PubMed |
description | BACKGROUND/AIMS: Less invasive surgical treatment is performed in East Asia to preserve postoperative digestive function and reduce complications such as postgastrectomy syndromes, but there is an issue of metachronous gastric cancer (GC) in the remaining stomach. This study aimed to analyze the incidence of metachronous GC and its risk factors in patients who had undergone partial gastrectomy. METHODS: A total of 3,045 GC patients who had undergone curative gastric partial resection at Seoul National University Bundang Hospital were enrolled and analyzed retrospectively for risk factors, including age, sex, smoking, alcohol, Helicobacter pylori status, family history of GC, histological type, and surgical method. RESULTS: Metachronous GC in the remaining stomach occurred in 35 of the 3,045 patients (1.1%) 23 in the distal gastrectomy group (18 with Billroth-I anastomosis, five with Billroth-II anastomosis), seven in the proximal gastrectomy (PG) group, and five in the pylorus-preserving gastrectomy (PPG) group. Univariate and multivariate Cox regression analyses showed that age ≥60 years (p=0.005) and surgical method used (PG or PPG, p<0.001) were related risk factors for metachronous GC, while male sex and intestinal type histology were potential risk factors. CONCLUSIONS: Metachronous GC was shown to be related to older age and the surgical method used (PG or PPG). Regular and careful follow-up with endoscopy should be performed in the case of gastric partial resection, especially in patients with male sex and intestinal type histology as well as those aged ≥60 years undergoing the PG or PPG surgical method. |
format | Online Article Text |
id | pubmed-9099384 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Editorial Office of Gut and Liver |
record_format | MEDLINE/PubMed |
spelling | pubmed-90993842022-05-19 The Incidence and Risk Factors for Metachronous Gastric Cancer in the Remnant Stomach after Gastric Cancer Surgery Choi, Yonghoon Kim, Nayoung Yoon, Hyuk Shin, Cheol Min Park, Young Soo Lee, Dong Ho Park, Young Suk Ahn, Sang-Hoon Suh, Yun-Suhk Park, Do Joong Kim, Hyung Ho Gut Liver Original Article BACKGROUND/AIMS: Less invasive surgical treatment is performed in East Asia to preserve postoperative digestive function and reduce complications such as postgastrectomy syndromes, but there is an issue of metachronous gastric cancer (GC) in the remaining stomach. This study aimed to analyze the incidence of metachronous GC and its risk factors in patients who had undergone partial gastrectomy. METHODS: A total of 3,045 GC patients who had undergone curative gastric partial resection at Seoul National University Bundang Hospital were enrolled and analyzed retrospectively for risk factors, including age, sex, smoking, alcohol, Helicobacter pylori status, family history of GC, histological type, and surgical method. RESULTS: Metachronous GC in the remaining stomach occurred in 35 of the 3,045 patients (1.1%) 23 in the distal gastrectomy group (18 with Billroth-I anastomosis, five with Billroth-II anastomosis), seven in the proximal gastrectomy (PG) group, and five in the pylorus-preserving gastrectomy (PPG) group. Univariate and multivariate Cox regression analyses showed that age ≥60 years (p=0.005) and surgical method used (PG or PPG, p<0.001) were related risk factors for metachronous GC, while male sex and intestinal type histology were potential risk factors. CONCLUSIONS: Metachronous GC was shown to be related to older age and the surgical method used (PG or PPG). Regular and careful follow-up with endoscopy should be performed in the case of gastric partial resection, especially in patients with male sex and intestinal type histology as well as those aged ≥60 years undergoing the PG or PPG surgical method. Editorial Office of Gut and Liver 2022-05-15 2021-09-01 /pmc/articles/PMC9099384/ /pubmed/34462394 http://dx.doi.org/10.5009/gnl210202 Text en Copyright © Gut and Liver. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Choi, Yonghoon Kim, Nayoung Yoon, Hyuk Shin, Cheol Min Park, Young Soo Lee, Dong Ho Park, Young Suk Ahn, Sang-Hoon Suh, Yun-Suhk Park, Do Joong Kim, Hyung Ho The Incidence and Risk Factors for Metachronous Gastric Cancer in the Remnant Stomach after Gastric Cancer Surgery |
title | The Incidence and Risk Factors for Metachronous Gastric Cancer in the Remnant Stomach after Gastric Cancer Surgery |
title_full | The Incidence and Risk Factors for Metachronous Gastric Cancer in the Remnant Stomach after Gastric Cancer Surgery |
title_fullStr | The Incidence and Risk Factors for Metachronous Gastric Cancer in the Remnant Stomach after Gastric Cancer Surgery |
title_full_unstemmed | The Incidence and Risk Factors for Metachronous Gastric Cancer in the Remnant Stomach after Gastric Cancer Surgery |
title_short | The Incidence and Risk Factors for Metachronous Gastric Cancer in the Remnant Stomach after Gastric Cancer Surgery |
title_sort | incidence and risk factors for metachronous gastric cancer in the remnant stomach after gastric cancer surgery |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099384/ https://www.ncbi.nlm.nih.gov/pubmed/34462394 http://dx.doi.org/10.5009/gnl210202 |
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