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Elevated Axonal Protein Markers Following Repetitive Blast Exposure in Military Personnel
Blast exposures that occur during training are common in military personnel; however, the biomarkers that relate to these subtle injuries is not well understood. Therefore, the purpose of this study is to identify the acute biomarkers related to blast injury in a cohort of military personnel exposur...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099432/ https://www.ncbi.nlm.nih.gov/pubmed/35573288 http://dx.doi.org/10.3389/fnins.2022.853616 |
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author | Vorn, Rany Naunheim, Rosanne Lai, Chen Wagner, Chelsea Gill, Jessica M. |
author_facet | Vorn, Rany Naunheim, Rosanne Lai, Chen Wagner, Chelsea Gill, Jessica M. |
author_sort | Vorn, Rany |
collection | PubMed |
description | Blast exposures that occur during training are common in military personnel; however, the biomarkers that relate to these subtle injuries is not well understood. Therefore, the purpose of this study is to identify the acute biomarkers related to blast injury in a cohort of military personnel exposure to blast-related training. Thirty-four military personnel who participated in the training program were included in this study. Blood samples were collected before and after repetitive blast-related training on days 2 (n = 19) and days 7 (n = 15). Serum concentration (pg/mL) of tau, glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), and phosphorylated tau181 (p-tau181) were measured using an ultrasensitive immunoassay platform. We observed that serum p-tau181 concentrations were elevated after exposed to repetitive blast on days 2 (z = −2.983, p = 0.003) and days 7 (z = −2.158, p = 0.031). Serum tau (z = −2.272, p = 0.023) and NfL (z = −2.158, p = 0.031) levels were significantly elevated after exposure to repetitive blasts on days 7. Our findings indicate that blast exposure affects serum biomarkers indicating axonal injury. |
format | Online Article Text |
id | pubmed-9099432 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90994322022-05-14 Elevated Axonal Protein Markers Following Repetitive Blast Exposure in Military Personnel Vorn, Rany Naunheim, Rosanne Lai, Chen Wagner, Chelsea Gill, Jessica M. Front Neurosci Neuroscience Blast exposures that occur during training are common in military personnel; however, the biomarkers that relate to these subtle injuries is not well understood. Therefore, the purpose of this study is to identify the acute biomarkers related to blast injury in a cohort of military personnel exposure to blast-related training. Thirty-four military personnel who participated in the training program were included in this study. Blood samples were collected before and after repetitive blast-related training on days 2 (n = 19) and days 7 (n = 15). Serum concentration (pg/mL) of tau, glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), and phosphorylated tau181 (p-tau181) were measured using an ultrasensitive immunoassay platform. We observed that serum p-tau181 concentrations were elevated after exposed to repetitive blast on days 2 (z = −2.983, p = 0.003) and days 7 (z = −2.158, p = 0.031). Serum tau (z = −2.272, p = 0.023) and NfL (z = −2.158, p = 0.031) levels were significantly elevated after exposure to repetitive blasts on days 7. Our findings indicate that blast exposure affects serum biomarkers indicating axonal injury. Frontiers Media S.A. 2022-04-29 /pmc/articles/PMC9099432/ /pubmed/35573288 http://dx.doi.org/10.3389/fnins.2022.853616 Text en Copyright © 2022 Vorn, Naunheim, Lai, Wagner and Gill. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Vorn, Rany Naunheim, Rosanne Lai, Chen Wagner, Chelsea Gill, Jessica M. Elevated Axonal Protein Markers Following Repetitive Blast Exposure in Military Personnel |
title | Elevated Axonal Protein Markers Following Repetitive Blast Exposure in Military Personnel |
title_full | Elevated Axonal Protein Markers Following Repetitive Blast Exposure in Military Personnel |
title_fullStr | Elevated Axonal Protein Markers Following Repetitive Blast Exposure in Military Personnel |
title_full_unstemmed | Elevated Axonal Protein Markers Following Repetitive Blast Exposure in Military Personnel |
title_short | Elevated Axonal Protein Markers Following Repetitive Blast Exposure in Military Personnel |
title_sort | elevated axonal protein markers following repetitive blast exposure in military personnel |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099432/ https://www.ncbi.nlm.nih.gov/pubmed/35573288 http://dx.doi.org/10.3389/fnins.2022.853616 |
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