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Synthesis and Characterization of Dihydrouracil Analogs Utilizing Biginelli Hybrids
Dihydrouracil presents a crucial intermediate in the catabolism of uracil. The vital importance of uracil and its nucleoside, uridine, encourages scientists to synthesize novel dihydrouracils. In this paper, we present an innovative, fast, and effective method for the synthesis of dihydrouracils. He...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099458/ https://www.ncbi.nlm.nih.gov/pubmed/35566289 http://dx.doi.org/10.3390/molecules27092939 |
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author | Bukhari, Syed Nasir Abbas Ejaz, Hasan Elsherif, Mervat A. Janković, Nenad |
author_facet | Bukhari, Syed Nasir Abbas Ejaz, Hasan Elsherif, Mervat A. Janković, Nenad |
author_sort | Bukhari, Syed Nasir Abbas |
collection | PubMed |
description | Dihydrouracil presents a crucial intermediate in the catabolism of uracil. The vital importance of uracil and its nucleoside, uridine, encourages scientists to synthesize novel dihydrouracils. In this paper, we present an innovative, fast, and effective method for the synthesis of dihydrouracils. Hence, under mild conditions, 3-chloroperbenzoic acid was used to cleave the carbon–sulfur bond of the Biginelli hybrids 5,6-dihydropyrimidin-4(3H)-ones. This approach led to thirteen novel dihydrouracils synthesized in moderate-to-high yields (32–99%). |
format | Online Article Text |
id | pubmed-9099458 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90994582022-05-14 Synthesis and Characterization of Dihydrouracil Analogs Utilizing Biginelli Hybrids Bukhari, Syed Nasir Abbas Ejaz, Hasan Elsherif, Mervat A. Janković, Nenad Molecules Article Dihydrouracil presents a crucial intermediate in the catabolism of uracil. The vital importance of uracil and its nucleoside, uridine, encourages scientists to synthesize novel dihydrouracils. In this paper, we present an innovative, fast, and effective method for the synthesis of dihydrouracils. Hence, under mild conditions, 3-chloroperbenzoic acid was used to cleave the carbon–sulfur bond of the Biginelli hybrids 5,6-dihydropyrimidin-4(3H)-ones. This approach led to thirteen novel dihydrouracils synthesized in moderate-to-high yields (32–99%). MDPI 2022-05-04 /pmc/articles/PMC9099458/ /pubmed/35566289 http://dx.doi.org/10.3390/molecules27092939 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bukhari, Syed Nasir Abbas Ejaz, Hasan Elsherif, Mervat A. Janković, Nenad Synthesis and Characterization of Dihydrouracil Analogs Utilizing Biginelli Hybrids |
title | Synthesis and Characterization of Dihydrouracil Analogs Utilizing Biginelli Hybrids |
title_full | Synthesis and Characterization of Dihydrouracil Analogs Utilizing Biginelli Hybrids |
title_fullStr | Synthesis and Characterization of Dihydrouracil Analogs Utilizing Biginelli Hybrids |
title_full_unstemmed | Synthesis and Characterization of Dihydrouracil Analogs Utilizing Biginelli Hybrids |
title_short | Synthesis and Characterization of Dihydrouracil Analogs Utilizing Biginelli Hybrids |
title_sort | synthesis and characterization of dihydrouracil analogs utilizing biginelli hybrids |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099458/ https://www.ncbi.nlm.nih.gov/pubmed/35566289 http://dx.doi.org/10.3390/molecules27092939 |
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