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Synthesis and Characterization of Dihydrouracil Analogs Utilizing Biginelli Hybrids

Dihydrouracil presents a crucial intermediate in the catabolism of uracil. The vital importance of uracil and its nucleoside, uridine, encourages scientists to synthesize novel dihydrouracils. In this paper, we present an innovative, fast, and effective method for the synthesis of dihydrouracils. He...

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Autores principales: Bukhari, Syed Nasir Abbas, Ejaz, Hasan, Elsherif, Mervat A., Janković, Nenad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099458/
https://www.ncbi.nlm.nih.gov/pubmed/35566289
http://dx.doi.org/10.3390/molecules27092939
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author Bukhari, Syed Nasir Abbas
Ejaz, Hasan
Elsherif, Mervat A.
Janković, Nenad
author_facet Bukhari, Syed Nasir Abbas
Ejaz, Hasan
Elsherif, Mervat A.
Janković, Nenad
author_sort Bukhari, Syed Nasir Abbas
collection PubMed
description Dihydrouracil presents a crucial intermediate in the catabolism of uracil. The vital importance of uracil and its nucleoside, uridine, encourages scientists to synthesize novel dihydrouracils. In this paper, we present an innovative, fast, and effective method for the synthesis of dihydrouracils. Hence, under mild conditions, 3-chloroperbenzoic acid was used to cleave the carbon–sulfur bond of the Biginelli hybrids 5,6-dihydropyrimidin-4(3H)-ones. This approach led to thirteen novel dihydrouracils synthesized in moderate-to-high yields (32–99%).
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spelling pubmed-90994582022-05-14 Synthesis and Characterization of Dihydrouracil Analogs Utilizing Biginelli Hybrids Bukhari, Syed Nasir Abbas Ejaz, Hasan Elsherif, Mervat A. Janković, Nenad Molecules Article Dihydrouracil presents a crucial intermediate in the catabolism of uracil. The vital importance of uracil and its nucleoside, uridine, encourages scientists to synthesize novel dihydrouracils. In this paper, we present an innovative, fast, and effective method for the synthesis of dihydrouracils. Hence, under mild conditions, 3-chloroperbenzoic acid was used to cleave the carbon–sulfur bond of the Biginelli hybrids 5,6-dihydropyrimidin-4(3H)-ones. This approach led to thirteen novel dihydrouracils synthesized in moderate-to-high yields (32–99%). MDPI 2022-05-04 /pmc/articles/PMC9099458/ /pubmed/35566289 http://dx.doi.org/10.3390/molecules27092939 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bukhari, Syed Nasir Abbas
Ejaz, Hasan
Elsherif, Mervat A.
Janković, Nenad
Synthesis and Characterization of Dihydrouracil Analogs Utilizing Biginelli Hybrids
title Synthesis and Characterization of Dihydrouracil Analogs Utilizing Biginelli Hybrids
title_full Synthesis and Characterization of Dihydrouracil Analogs Utilizing Biginelli Hybrids
title_fullStr Synthesis and Characterization of Dihydrouracil Analogs Utilizing Biginelli Hybrids
title_full_unstemmed Synthesis and Characterization of Dihydrouracil Analogs Utilizing Biginelli Hybrids
title_short Synthesis and Characterization of Dihydrouracil Analogs Utilizing Biginelli Hybrids
title_sort synthesis and characterization of dihydrouracil analogs utilizing biginelli hybrids
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099458/
https://www.ncbi.nlm.nih.gov/pubmed/35566289
http://dx.doi.org/10.3390/molecules27092939
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