The P2X7 Receptor Promotes Colorectal Inflammation and Tumorigenesis by Modulating Gut Microbiota and the Inflammasome

Background: Given the role of the P2X7 receptor (P2X7R) in inflammatory bowel diseases (IBD), we investigated its role in the development and progression of colitis-associated colorectal cancer (CA-CRC). Methods: CA-CRC was induced in P2X7R(+/+) and P2X7R(−/−) mice with azoxymethane (AOM) combined w...

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Detalles Bibliográficos
Autores principales: Bernardazzi, Claudio, Castelo-Branco, Morgana Teixeira Lima, Pêgo, Beatriz, Ribeiro, Beatriz Elias, Rosas, Siane Lopes Bittencourt, Santana, Patrícia Teixeira, Machado, João Carlos, Leal, Camille, Thompson, Fabiano, Coutinho-Silva, Robson, de Souza, Heitor Siffert Pereira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099551/
https://www.ncbi.nlm.nih.gov/pubmed/35563010
http://dx.doi.org/10.3390/ijms23094616

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099551/
https://www.ncbi.nlm.nih.gov/pubmed/35563010
http://dx.doi.org/10.3390/ijms23094616

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