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Analysis of a Pure Magnesium Membrane Degradation Process and Its Functionality When Used in a Guided Bone Regeneration Model in Beagle Dogs

For the surgical technique of guided bone regeneration (GBR), the choice of available barrier membranes has until recently not included an option that is mechanically strong, durable, synthetic and resorbable. The most commonly used resorbable membranes are made from collagen, which are restricted i...

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Autores principales: Rider, Patrick, Kačarević, Željka Perić, Elad, Akiva, Rothamel, Daniel, Sauer, Gerrit, Bornert, Fabien, Windisch, Peter, Hangyási, Dávid, Molnar, Balint, Hesse, Bernhard, Witte, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099583/
https://www.ncbi.nlm.nih.gov/pubmed/35591440
http://dx.doi.org/10.3390/ma15093106
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author Rider, Patrick
Kačarević, Željka Perić
Elad, Akiva
Rothamel, Daniel
Sauer, Gerrit
Bornert, Fabien
Windisch, Peter
Hangyási, Dávid
Molnar, Balint
Hesse, Bernhard
Witte, Frank
author_facet Rider, Patrick
Kačarević, Željka Perić
Elad, Akiva
Rothamel, Daniel
Sauer, Gerrit
Bornert, Fabien
Windisch, Peter
Hangyási, Dávid
Molnar, Balint
Hesse, Bernhard
Witte, Frank
author_sort Rider, Patrick
collection PubMed
description For the surgical technique of guided bone regeneration (GBR), the choice of available barrier membranes has until recently not included an option that is mechanically strong, durable, synthetic and resorbable. The most commonly used resorbable membranes are made from collagen, which are restricted in their mechanical strength. The purpose of this study is to evaluate the degradation and regeneration potential of a magnesium membrane compared to a collagen membrane. In eighteen beagle dogs, experimental bone defects were filled with bovine xenograft and covered with either a magnesium membrane or collagen membrane. The health status of the animals was regularly monitored and recorded. Following sacrifice, the hemimandibles were prepared for micro-CT (μ-CT) analysis. Complications during healing were observed in both groups, but ultimately, the regenerative outcome was similar between groups. The μ-CT parameters showed comparable results in both groups in terms of new bone formation at all four time points. In addition, the μ-CT analysis showed that the greatest degradation of the magnesium membranes occurred between 1 and 8 weeks and continued until week 16. The proportion of new bone within the defect site was similar for both treatment groups, indicating the potential for the magnesium membrane to be used as a viable alternative to collagen membranes. Overall, the new magnesium membrane is a functional and safe membrane for the treatment of defects according to the principles of GBR.
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spelling pubmed-90995832022-05-14 Analysis of a Pure Magnesium Membrane Degradation Process and Its Functionality When Used in a Guided Bone Regeneration Model in Beagle Dogs Rider, Patrick Kačarević, Željka Perić Elad, Akiva Rothamel, Daniel Sauer, Gerrit Bornert, Fabien Windisch, Peter Hangyási, Dávid Molnar, Balint Hesse, Bernhard Witte, Frank Materials (Basel) Article For the surgical technique of guided bone regeneration (GBR), the choice of available barrier membranes has until recently not included an option that is mechanically strong, durable, synthetic and resorbable. The most commonly used resorbable membranes are made from collagen, which are restricted in their mechanical strength. The purpose of this study is to evaluate the degradation and regeneration potential of a magnesium membrane compared to a collagen membrane. In eighteen beagle dogs, experimental bone defects were filled with bovine xenograft and covered with either a magnesium membrane or collagen membrane. The health status of the animals was regularly monitored and recorded. Following sacrifice, the hemimandibles were prepared for micro-CT (μ-CT) analysis. Complications during healing were observed in both groups, but ultimately, the regenerative outcome was similar between groups. The μ-CT parameters showed comparable results in both groups in terms of new bone formation at all four time points. In addition, the μ-CT analysis showed that the greatest degradation of the magnesium membranes occurred between 1 and 8 weeks and continued until week 16. The proportion of new bone within the defect site was similar for both treatment groups, indicating the potential for the magnesium membrane to be used as a viable alternative to collagen membranes. Overall, the new magnesium membrane is a functional and safe membrane for the treatment of defects according to the principles of GBR. MDPI 2022-04-25 /pmc/articles/PMC9099583/ /pubmed/35591440 http://dx.doi.org/10.3390/ma15093106 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rider, Patrick
Kačarević, Željka Perić
Elad, Akiva
Rothamel, Daniel
Sauer, Gerrit
Bornert, Fabien
Windisch, Peter
Hangyási, Dávid
Molnar, Balint
Hesse, Bernhard
Witte, Frank
Analysis of a Pure Magnesium Membrane Degradation Process and Its Functionality When Used in a Guided Bone Regeneration Model in Beagle Dogs
title Analysis of a Pure Magnesium Membrane Degradation Process and Its Functionality When Used in a Guided Bone Regeneration Model in Beagle Dogs
title_full Analysis of a Pure Magnesium Membrane Degradation Process and Its Functionality When Used in a Guided Bone Regeneration Model in Beagle Dogs
title_fullStr Analysis of a Pure Magnesium Membrane Degradation Process and Its Functionality When Used in a Guided Bone Regeneration Model in Beagle Dogs
title_full_unstemmed Analysis of a Pure Magnesium Membrane Degradation Process and Its Functionality When Used in a Guided Bone Regeneration Model in Beagle Dogs
title_short Analysis of a Pure Magnesium Membrane Degradation Process and Its Functionality When Used in a Guided Bone Regeneration Model in Beagle Dogs
title_sort analysis of a pure magnesium membrane degradation process and its functionality when used in a guided bone regeneration model in beagle dogs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099583/
https://www.ncbi.nlm.nih.gov/pubmed/35591440
http://dx.doi.org/10.3390/ma15093106
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