Cargando…
The Administration of Panax Ginseng Berry Extract Attenuates High-Fat-Diet-Induced Sarcopenic Obesity in C57BL/6 Mice
Sarcopenia and obesity are serious health problems that are highly related to several metabolic diseases. Sarcopenic obesity, a combined state of sarcopenia and obesity, results in higher risks of metabolic diseases and even mortality than sarcopenia or obesity alone. Therefore, the development of t...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099595/ https://www.ncbi.nlm.nih.gov/pubmed/35565712 http://dx.doi.org/10.3390/nu14091747 |
_version_ | 1784706644834254848 |
---|---|
author | Shin, Ji-Eun Jeon, So-Hyun Lee, Sang-Jun Choung, Se-Young |
author_facet | Shin, Ji-Eun Jeon, So-Hyun Lee, Sang-Jun Choung, Se-Young |
author_sort | Shin, Ji-Eun |
collection | PubMed |
description | Sarcopenia and obesity are serious health problems that are highly related to several metabolic diseases. Sarcopenic obesity, a combined state of sarcopenia and obesity, results in higher risks of metabolic diseases and even mortality than sarcopenia or obesity alone. Therefore, the development of therapeutic agents for sarcopenic obesity is crucial. C57BL/6 mice were fed with a high-fat diet (HFD) for 9 weeks. Then, mice were administered with Panax ginseng berry extract (GBE) for an additional 4 weeks, with continuous HFD intake. GBE significantly decreased the food efficiency ratio, serum lipid and insulin levels, adipose tissue weights, and adipocyte size. It significantly increased the grip strength, muscle masses, and myofiber cross-sectional area. It deactivated the protein kinase C (PKC) theta and zeta, resulting in activation of the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) pathway, which is known to regulate muscle synthesis and degradation. Furthermore, it inhibited the production of inflammatory cytokines in the muscle tissue. GBE attenuated both obesity and sarcopenia. Thus, GBE is a potential agent to prevent or treat sarcopenic obesity. |
format | Online Article Text |
id | pubmed-9099595 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90995952022-05-14 The Administration of Panax Ginseng Berry Extract Attenuates High-Fat-Diet-Induced Sarcopenic Obesity in C57BL/6 Mice Shin, Ji-Eun Jeon, So-Hyun Lee, Sang-Jun Choung, Se-Young Nutrients Article Sarcopenia and obesity are serious health problems that are highly related to several metabolic diseases. Sarcopenic obesity, a combined state of sarcopenia and obesity, results in higher risks of metabolic diseases and even mortality than sarcopenia or obesity alone. Therefore, the development of therapeutic agents for sarcopenic obesity is crucial. C57BL/6 mice were fed with a high-fat diet (HFD) for 9 weeks. Then, mice were administered with Panax ginseng berry extract (GBE) for an additional 4 weeks, with continuous HFD intake. GBE significantly decreased the food efficiency ratio, serum lipid and insulin levels, adipose tissue weights, and adipocyte size. It significantly increased the grip strength, muscle masses, and myofiber cross-sectional area. It deactivated the protein kinase C (PKC) theta and zeta, resulting in activation of the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) pathway, which is known to regulate muscle synthesis and degradation. Furthermore, it inhibited the production of inflammatory cytokines in the muscle tissue. GBE attenuated both obesity and sarcopenia. Thus, GBE is a potential agent to prevent or treat sarcopenic obesity. MDPI 2022-04-22 /pmc/articles/PMC9099595/ /pubmed/35565712 http://dx.doi.org/10.3390/nu14091747 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Shin, Ji-Eun Jeon, So-Hyun Lee, Sang-Jun Choung, Se-Young The Administration of Panax Ginseng Berry Extract Attenuates High-Fat-Diet-Induced Sarcopenic Obesity in C57BL/6 Mice |
title | The Administration of Panax Ginseng Berry Extract Attenuates High-Fat-Diet-Induced Sarcopenic Obesity in C57BL/6 Mice |
title_full | The Administration of Panax Ginseng Berry Extract Attenuates High-Fat-Diet-Induced Sarcopenic Obesity in C57BL/6 Mice |
title_fullStr | The Administration of Panax Ginseng Berry Extract Attenuates High-Fat-Diet-Induced Sarcopenic Obesity in C57BL/6 Mice |
title_full_unstemmed | The Administration of Panax Ginseng Berry Extract Attenuates High-Fat-Diet-Induced Sarcopenic Obesity in C57BL/6 Mice |
title_short | The Administration of Panax Ginseng Berry Extract Attenuates High-Fat-Diet-Induced Sarcopenic Obesity in C57BL/6 Mice |
title_sort | administration of panax ginseng berry extract attenuates high-fat-diet-induced sarcopenic obesity in c57bl/6 mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099595/ https://www.ncbi.nlm.nih.gov/pubmed/35565712 http://dx.doi.org/10.3390/nu14091747 |
work_keys_str_mv | AT shinjieun theadministrationofpanaxginsengberryextractattenuateshighfatdietinducedsarcopenicobesityinc57bl6mice AT jeonsohyun theadministrationofpanaxginsengberryextractattenuateshighfatdietinducedsarcopenicobesityinc57bl6mice AT leesangjun theadministrationofpanaxginsengberryextractattenuateshighfatdietinducedsarcopenicobesityinc57bl6mice AT choungseyoung theadministrationofpanaxginsengberryextractattenuateshighfatdietinducedsarcopenicobesityinc57bl6mice AT shinjieun administrationofpanaxginsengberryextractattenuateshighfatdietinducedsarcopenicobesityinc57bl6mice AT jeonsohyun administrationofpanaxginsengberryextractattenuateshighfatdietinducedsarcopenicobesityinc57bl6mice AT leesangjun administrationofpanaxginsengberryextractattenuateshighfatdietinducedsarcopenicobesityinc57bl6mice AT choungseyoung administrationofpanaxginsengberryextractattenuateshighfatdietinducedsarcopenicobesityinc57bl6mice |