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Effects of Epigenetic Modification of PGC-1α by a Chemical Chaperon on Mitochondria Biogenesis and Visual Function in Retinitis Pigmentosa

Retinitis pigmentosa (RP) is a hereditary blinding disease characterized by gradual photoreceptor death, which lacks a definitive treatment. Here, we demonstrated the effect of 4-phenylbutyric acid (PBA), a chemical chaperon that can suppress endoplasmic reticulum (ER) stress, in P23H mutant rhodops...

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Detalles Bibliográficos
Autores principales:	Ozawa, Yoko, Toda, Eriko, Homma, Kohei, Osada, Hideto, Nagai, Norihiro, Tsubota, Kazuo, Okano, Hideyuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099608/ https://www.ncbi.nlm.nih.gov/pubmed/35563803 http://dx.doi.org/10.3390/cells11091497

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