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Soluble Epoxide Hydrolase as a Therapeutic Target for Neuropsychiatric Disorders
It has been found that soluble epoxide hydrolase (sEH; encoded by the EPHX2 gene) in the metabolism of polyunsaturated fatty acids (PUFAs) plays a key role in inflammation, which, in turn, plays a part in the pathogenesis of neuropsychiatric disorders. Meanwhile, epoxy fatty acids such as epoxyeicos...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099663/ https://www.ncbi.nlm.nih.gov/pubmed/35563342 http://dx.doi.org/10.3390/ijms23094951 |
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author | Shan, Jiajing Hashimoto, Kenji |
author_facet | Shan, Jiajing Hashimoto, Kenji |
author_sort | Shan, Jiajing |
collection | PubMed |
description | It has been found that soluble epoxide hydrolase (sEH; encoded by the EPHX2 gene) in the metabolism of polyunsaturated fatty acids (PUFAs) plays a key role in inflammation, which, in turn, plays a part in the pathogenesis of neuropsychiatric disorders. Meanwhile, epoxy fatty acids such as epoxyeicosatrienoic acids (EETs), epoxyeicosatetraenoic acids (EEQs), and epoxyeicosapentaenoic acids (EDPs) have been found to exert neuroprotective effects in animal models of neuropsychiatric disorders through potent anti-inflammatory actions. Soluble expoxide hydrolase, an enzyme present in all living organisms, metabolizes epoxy fatty acids into the corresponding dihydroxy fatty acids, which are less active than the precursors. In this regard, preclinical findings using sEH inhibitors or Ephx2 knock-out (KO) mice have indicated that the inhibition or deficiency of sEH can have beneficial effects in several models of neuropsychiatric disorders. Thus, this review discusses the current findings of the role of sEH in neuropsychiatric disorders, including depression, autism spectrum disorder (ASD), schizophrenia, Parkinson’s disease (PD), and stroke, as well as the potential mechanisms underlying the therapeutic effects of sEH inhibitors. |
format | Online Article Text |
id | pubmed-9099663 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90996632022-05-14 Soluble Epoxide Hydrolase as a Therapeutic Target for Neuropsychiatric Disorders Shan, Jiajing Hashimoto, Kenji Int J Mol Sci Review It has been found that soluble epoxide hydrolase (sEH; encoded by the EPHX2 gene) in the metabolism of polyunsaturated fatty acids (PUFAs) plays a key role in inflammation, which, in turn, plays a part in the pathogenesis of neuropsychiatric disorders. Meanwhile, epoxy fatty acids such as epoxyeicosatrienoic acids (EETs), epoxyeicosatetraenoic acids (EEQs), and epoxyeicosapentaenoic acids (EDPs) have been found to exert neuroprotective effects in animal models of neuropsychiatric disorders through potent anti-inflammatory actions. Soluble expoxide hydrolase, an enzyme present in all living organisms, metabolizes epoxy fatty acids into the corresponding dihydroxy fatty acids, which are less active than the precursors. In this regard, preclinical findings using sEH inhibitors or Ephx2 knock-out (KO) mice have indicated that the inhibition or deficiency of sEH can have beneficial effects in several models of neuropsychiatric disorders. Thus, this review discusses the current findings of the role of sEH in neuropsychiatric disorders, including depression, autism spectrum disorder (ASD), schizophrenia, Parkinson’s disease (PD), and stroke, as well as the potential mechanisms underlying the therapeutic effects of sEH inhibitors. MDPI 2022-04-29 /pmc/articles/PMC9099663/ /pubmed/35563342 http://dx.doi.org/10.3390/ijms23094951 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Shan, Jiajing Hashimoto, Kenji Soluble Epoxide Hydrolase as a Therapeutic Target for Neuropsychiatric Disorders |
title | Soluble Epoxide Hydrolase as a Therapeutic Target for Neuropsychiatric Disorders |
title_full | Soluble Epoxide Hydrolase as a Therapeutic Target for Neuropsychiatric Disorders |
title_fullStr | Soluble Epoxide Hydrolase as a Therapeutic Target for Neuropsychiatric Disorders |
title_full_unstemmed | Soluble Epoxide Hydrolase as a Therapeutic Target for Neuropsychiatric Disorders |
title_short | Soluble Epoxide Hydrolase as a Therapeutic Target for Neuropsychiatric Disorders |
title_sort | soluble epoxide hydrolase as a therapeutic target for neuropsychiatric disorders |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099663/ https://www.ncbi.nlm.nih.gov/pubmed/35563342 http://dx.doi.org/10.3390/ijms23094951 |
work_keys_str_mv | AT shanjiajing solubleepoxidehydrolaseasatherapeutictargetforneuropsychiatricdisorders AT hashimotokenji solubleepoxidehydrolaseasatherapeutictargetforneuropsychiatricdisorders |