Tumour Stem Cells in Breast Cancer

Tumour stem cells (CSCs) are a self-renewing population that plays important roles in tumour initiation, recurrence, and metastasis. Although the medical literature is extensive, problems with CSC identification and cancer therapy remain. This review provides the main mechanisms of CSC action in bre...

Descripción completa

Detalles Bibliográficos
Autores principales: Ibragimova, Marina, Tsyganov, Matvey, Litviakov, Nikolai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099719/
https://www.ncbi.nlm.nih.gov/pubmed/35563449
http://dx.doi.org/10.3390/ijms23095058
Descripción
Sumario:Tumour stem cells (CSCs) are a self-renewing population that plays important roles in tumour initiation, recurrence, and metastasis. Although the medical literature is extensive, problems with CSC identification and cancer therapy remain. This review provides the main mechanisms of CSC action in breast cancer (BC): CSC markers and signalling pathways, heterogeneity, plasticity, and ecological behaviour. The dynamic heterogeneity of CSCs and the dynamic transitions of CSC(−) non-CSCs and their significance for metastasis are considered.

Ejemplares similares