p97/UBXD1 Generate Ubiquitylated Proteins That Are Sequestered into Nuclear Envelope Herniations in Torsin-Deficient Cells

DYT1 dystonia is a debilitating neurological movement disorder that arises upon Torsin ATPase deficiency. Nuclear envelope (NE) blebs that contain FG-nucleoporins (FG-Nups) and K48-linked ubiquitin are the hallmark phenotype of Torsin manipulation across disease models of DYT1 dystonia. While the ab...

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Detalles Bibliográficos
Autores principales: Prophet, Sarah M., Naughton, Brigitte S., Schlieker, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9100061/
https://www.ncbi.nlm.nih.gov/pubmed/35563018
http://dx.doi.org/10.3390/ijms23094627

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9100061/
https://www.ncbi.nlm.nih.gov/pubmed/35563018
http://dx.doi.org/10.3390/ijms23094627

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