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Ocular Ischemic Syndrome and Its Related Experimental Models

Ocular ischemic syndrome (OIS) is one of the severe ocular disorders occurring from stenosis or occlusion of the carotid arteries. As the ophthalmic artery is derived from the branch of the carotid artery, stenosis or occlusion of the carotid arteries could induce chronic ocular hypoperfusion, final...

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Autores principales: Lee, Deokho, Tomita, Yohei, Yang, Lizhu, Negishi, Kazuno, Kurihara, Toshihide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9100201/
https://www.ncbi.nlm.nih.gov/pubmed/35563640
http://dx.doi.org/10.3390/ijms23095249
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author Lee, Deokho
Tomita, Yohei
Yang, Lizhu
Negishi, Kazuno
Kurihara, Toshihide
author_facet Lee, Deokho
Tomita, Yohei
Yang, Lizhu
Negishi, Kazuno
Kurihara, Toshihide
author_sort Lee, Deokho
collection PubMed
description Ocular ischemic syndrome (OIS) is one of the severe ocular disorders occurring from stenosis or occlusion of the carotid arteries. As the ophthalmic artery is derived from the branch of the carotid artery, stenosis or occlusion of the carotid arteries could induce chronic ocular hypoperfusion, finally leading to the development of OIS. To date, the pathophysiology of OIS is still not clearly unraveled. To better explore the pathophysiology of OIS, several experimental models have been developed in rats and mice. Surgical occlusion or stenosis of common carotid arteries or internal carotid arteries was conducted bilaterally or unilaterally for model development. In this regard, final ischemic outcomes in the eye varied depending on the surgical procedure, even though similar findings on ocular hypoperfusion could be observed. In the current review, we provide an overview of the pathophysiology of OIS from various experimental models, as well as several clinical cases. Moreover, we cover the status of current therapies for OIS along with promising preclinical treatments with recent advances. Our review will enable more comprehensive therapeutic approaches to prevent the development and/or progression of OIS.
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spelling pubmed-91002012022-05-14 Ocular Ischemic Syndrome and Its Related Experimental Models Lee, Deokho Tomita, Yohei Yang, Lizhu Negishi, Kazuno Kurihara, Toshihide Int J Mol Sci Review Ocular ischemic syndrome (OIS) is one of the severe ocular disorders occurring from stenosis or occlusion of the carotid arteries. As the ophthalmic artery is derived from the branch of the carotid artery, stenosis or occlusion of the carotid arteries could induce chronic ocular hypoperfusion, finally leading to the development of OIS. To date, the pathophysiology of OIS is still not clearly unraveled. To better explore the pathophysiology of OIS, several experimental models have been developed in rats and mice. Surgical occlusion or stenosis of common carotid arteries or internal carotid arteries was conducted bilaterally or unilaterally for model development. In this regard, final ischemic outcomes in the eye varied depending on the surgical procedure, even though similar findings on ocular hypoperfusion could be observed. In the current review, we provide an overview of the pathophysiology of OIS from various experimental models, as well as several clinical cases. Moreover, we cover the status of current therapies for OIS along with promising preclinical treatments with recent advances. Our review will enable more comprehensive therapeutic approaches to prevent the development and/or progression of OIS. MDPI 2022-05-08 /pmc/articles/PMC9100201/ /pubmed/35563640 http://dx.doi.org/10.3390/ijms23095249 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lee, Deokho
Tomita, Yohei
Yang, Lizhu
Negishi, Kazuno
Kurihara, Toshihide
Ocular Ischemic Syndrome and Its Related Experimental Models
title Ocular Ischemic Syndrome and Its Related Experimental Models
title_full Ocular Ischemic Syndrome and Its Related Experimental Models
title_fullStr Ocular Ischemic Syndrome and Its Related Experimental Models
title_full_unstemmed Ocular Ischemic Syndrome and Its Related Experimental Models
title_short Ocular Ischemic Syndrome and Its Related Experimental Models
title_sort ocular ischemic syndrome and its related experimental models
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9100201/
https://www.ncbi.nlm.nih.gov/pubmed/35563640
http://dx.doi.org/10.3390/ijms23095249
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