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Ocular Ischemic Syndrome and Its Related Experimental Models
Ocular ischemic syndrome (OIS) is one of the severe ocular disorders occurring from stenosis or occlusion of the carotid arteries. As the ophthalmic artery is derived from the branch of the carotid artery, stenosis or occlusion of the carotid arteries could induce chronic ocular hypoperfusion, final...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9100201/ https://www.ncbi.nlm.nih.gov/pubmed/35563640 http://dx.doi.org/10.3390/ijms23095249 |
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author | Lee, Deokho Tomita, Yohei Yang, Lizhu Negishi, Kazuno Kurihara, Toshihide |
author_facet | Lee, Deokho Tomita, Yohei Yang, Lizhu Negishi, Kazuno Kurihara, Toshihide |
author_sort | Lee, Deokho |
collection | PubMed |
description | Ocular ischemic syndrome (OIS) is one of the severe ocular disorders occurring from stenosis or occlusion of the carotid arteries. As the ophthalmic artery is derived from the branch of the carotid artery, stenosis or occlusion of the carotid arteries could induce chronic ocular hypoperfusion, finally leading to the development of OIS. To date, the pathophysiology of OIS is still not clearly unraveled. To better explore the pathophysiology of OIS, several experimental models have been developed in rats and mice. Surgical occlusion or stenosis of common carotid arteries or internal carotid arteries was conducted bilaterally or unilaterally for model development. In this regard, final ischemic outcomes in the eye varied depending on the surgical procedure, even though similar findings on ocular hypoperfusion could be observed. In the current review, we provide an overview of the pathophysiology of OIS from various experimental models, as well as several clinical cases. Moreover, we cover the status of current therapies for OIS along with promising preclinical treatments with recent advances. Our review will enable more comprehensive therapeutic approaches to prevent the development and/or progression of OIS. |
format | Online Article Text |
id | pubmed-9100201 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91002012022-05-14 Ocular Ischemic Syndrome and Its Related Experimental Models Lee, Deokho Tomita, Yohei Yang, Lizhu Negishi, Kazuno Kurihara, Toshihide Int J Mol Sci Review Ocular ischemic syndrome (OIS) is one of the severe ocular disorders occurring from stenosis or occlusion of the carotid arteries. As the ophthalmic artery is derived from the branch of the carotid artery, stenosis or occlusion of the carotid arteries could induce chronic ocular hypoperfusion, finally leading to the development of OIS. To date, the pathophysiology of OIS is still not clearly unraveled. To better explore the pathophysiology of OIS, several experimental models have been developed in rats and mice. Surgical occlusion or stenosis of common carotid arteries or internal carotid arteries was conducted bilaterally or unilaterally for model development. In this regard, final ischemic outcomes in the eye varied depending on the surgical procedure, even though similar findings on ocular hypoperfusion could be observed. In the current review, we provide an overview of the pathophysiology of OIS from various experimental models, as well as several clinical cases. Moreover, we cover the status of current therapies for OIS along with promising preclinical treatments with recent advances. Our review will enable more comprehensive therapeutic approaches to prevent the development and/or progression of OIS. MDPI 2022-05-08 /pmc/articles/PMC9100201/ /pubmed/35563640 http://dx.doi.org/10.3390/ijms23095249 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lee, Deokho Tomita, Yohei Yang, Lizhu Negishi, Kazuno Kurihara, Toshihide Ocular Ischemic Syndrome and Its Related Experimental Models |
title | Ocular Ischemic Syndrome and Its Related Experimental Models |
title_full | Ocular Ischemic Syndrome and Its Related Experimental Models |
title_fullStr | Ocular Ischemic Syndrome and Its Related Experimental Models |
title_full_unstemmed | Ocular Ischemic Syndrome and Its Related Experimental Models |
title_short | Ocular Ischemic Syndrome and Its Related Experimental Models |
title_sort | ocular ischemic syndrome and its related experimental models |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9100201/ https://www.ncbi.nlm.nih.gov/pubmed/35563640 http://dx.doi.org/10.3390/ijms23095249 |
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