Alchemical Design of Pharmacological Chaperones with Higher Affinity for Phenylalanine Hydroxylase

Phenylketonuria (PKU) is a rare metabolic disease caused by variations in a human gene, PAH, encoding phenylalanine hydroxylase (PAH), and the enzyme converting the essential amino acid phenylalanine into tyrosine. Many PKU-causing variations compromise the conformational stability of the encoded en...

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Detalles Bibliográficos
Autores principales: Conde-Giménez, María, Galano-Frutos, Juan José, Galiana-Cameo, María, Mahía, Alejandro, Victor, Bruno L., Salillas, Sandra, Velázquez-Campoy, Adrián, Brito, Rui M. M., Gálvez, José Antonio, Díaz-de-Villegas, María D., Sancho, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9100405/
https://www.ncbi.nlm.nih.gov/pubmed/35562892
http://dx.doi.org/10.3390/ijms23094502

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