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Frequency Nesting Interactions in the Subthalamic Nucleus Correlate With the Step Phases for Parkinson’s Disease
Gait disturbance in Parkinson’s disease (PD) can be ameliorated by sound stimulation. Given that excessive β synchronization in basal ganglia is linked to motor impairment in PD, whether the frequency nesting interactions are associated with the gait problem is far from clear. To this end, the maski...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9100409/ https://www.ncbi.nlm.nih.gov/pubmed/35574448 http://dx.doi.org/10.3389/fphys.2022.890753 |
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author | Jin, Luyao Shi, Wenbin Zhang, Chuting Yeh, Chien-Hung |
author_facet | Jin, Luyao Shi, Wenbin Zhang, Chuting Yeh, Chien-Hung |
author_sort | Jin, Luyao |
collection | PubMed |
description | Gait disturbance in Parkinson’s disease (PD) can be ameliorated by sound stimulation. Given that excessive β synchronization in basal ganglia is linked to motor impairment in PD, whether the frequency nesting interactions are associated with the gait problem is far from clear. To this end, the masking phase-amplitude coupling (PAC) method was proposed to overcome the trade-off between intrinsic nonlinearity/non-stationarity and demand for predetermined frequencies, normally extracted by the filter. In this study, we analyzed LFPs recorded from 13 patients (one female) with PD during stepping with bilateral deep brain electrodes implanted in the subthalamic nucleus (STN). We found that not only high-frequency oscillation (100–300 Hz) was modulated by β (13–30 Hz) but also β and γ amplitude were modulated by their low-frequency components in δ/θ/α and δ/θ/α/β bands. These PAC values were suppressed by sound stimulation, along with an improvement in gait. We also showed that gait-related high-β (Hβ) modulation in the STN was sensitive to auditory cues, and Hβ gait-phase modulation increased with a metronome. Meanwhile, phase-locking values (PLVs) across all frequencies were significantly suppressed around contralateral heel strikes, manifesting the contralateral step as a critical gait phase in gait initiation for PD. Only the PLVs around contralateral steps were sensitive to auditory cues. Our results support masking PAC as an effective method in exploring frequency nesting interactions in LFPs and reveal the linkages between sound stimulation and couplings related to gait phases in the STN. These findings raise the possibility that nesting interactions in the STN work as feasible biomarkers in alleviating gait disorders. |
format | Online Article Text |
id | pubmed-9100409 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91004092022-05-14 Frequency Nesting Interactions in the Subthalamic Nucleus Correlate With the Step Phases for Parkinson’s Disease Jin, Luyao Shi, Wenbin Zhang, Chuting Yeh, Chien-Hung Front Physiol Physiology Gait disturbance in Parkinson’s disease (PD) can be ameliorated by sound stimulation. Given that excessive β synchronization in basal ganglia is linked to motor impairment in PD, whether the frequency nesting interactions are associated with the gait problem is far from clear. To this end, the masking phase-amplitude coupling (PAC) method was proposed to overcome the trade-off between intrinsic nonlinearity/non-stationarity and demand for predetermined frequencies, normally extracted by the filter. In this study, we analyzed LFPs recorded from 13 patients (one female) with PD during stepping with bilateral deep brain electrodes implanted in the subthalamic nucleus (STN). We found that not only high-frequency oscillation (100–300 Hz) was modulated by β (13–30 Hz) but also β and γ amplitude were modulated by their low-frequency components in δ/θ/α and δ/θ/α/β bands. These PAC values were suppressed by sound stimulation, along with an improvement in gait. We also showed that gait-related high-β (Hβ) modulation in the STN was sensitive to auditory cues, and Hβ gait-phase modulation increased with a metronome. Meanwhile, phase-locking values (PLVs) across all frequencies were significantly suppressed around contralateral heel strikes, manifesting the contralateral step as a critical gait phase in gait initiation for PD. Only the PLVs around contralateral steps were sensitive to auditory cues. Our results support masking PAC as an effective method in exploring frequency nesting interactions in LFPs and reveal the linkages between sound stimulation and couplings related to gait phases in the STN. These findings raise the possibility that nesting interactions in the STN work as feasible biomarkers in alleviating gait disorders. Frontiers Media S.A. 2022-04-29 /pmc/articles/PMC9100409/ /pubmed/35574448 http://dx.doi.org/10.3389/fphys.2022.890753 Text en Copyright © 2022 Jin, Shi, Zhang and Yeh. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Jin, Luyao Shi, Wenbin Zhang, Chuting Yeh, Chien-Hung Frequency Nesting Interactions in the Subthalamic Nucleus Correlate With the Step Phases for Parkinson’s Disease |
title | Frequency Nesting Interactions in the Subthalamic Nucleus Correlate With the Step Phases for Parkinson’s Disease |
title_full | Frequency Nesting Interactions in the Subthalamic Nucleus Correlate With the Step Phases for Parkinson’s Disease |
title_fullStr | Frequency Nesting Interactions in the Subthalamic Nucleus Correlate With the Step Phases for Parkinson’s Disease |
title_full_unstemmed | Frequency Nesting Interactions in the Subthalamic Nucleus Correlate With the Step Phases for Parkinson’s Disease |
title_short | Frequency Nesting Interactions in the Subthalamic Nucleus Correlate With the Step Phases for Parkinson’s Disease |
title_sort | frequency nesting interactions in the subthalamic nucleus correlate with the step phases for parkinson’s disease |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9100409/ https://www.ncbi.nlm.nih.gov/pubmed/35574448 http://dx.doi.org/10.3389/fphys.2022.890753 |
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