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Long-term alterations in somatosensory functioning in survivors of childhood cancer
Cancer and its treatment can have lasting consequences on somatosensation, including pain, which is often underrecognized and undertreated. Research characterizing the impact of cancer on pain and sensory processing in survivors of childhood cancer is scarce. This study aimed to quantify generalized...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9100454/ https://www.ncbi.nlm.nih.gov/pubmed/34855647 http://dx.doi.org/10.1097/j.pain.0000000000002486 |
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author | Tutelman, Perri R. Chambers, Christine T. Cornelissen, Laura Fernandez, Conrad V. Flanders, Annette MacLeod, Julia Sherry, Simon B. Stewart, Sherry H. Urquhart, Robin de Gagne, Sitara Guilcher, Gregory M.T. Hashmi, Javeria Heathcote, Lauren C. Noel, Melanie Schulte, Fiona S.M. Stinson, Jennifer N. Stern, Maya |
author_facet | Tutelman, Perri R. Chambers, Christine T. Cornelissen, Laura Fernandez, Conrad V. Flanders, Annette MacLeod, Julia Sherry, Simon B. Stewart, Sherry H. Urquhart, Robin de Gagne, Sitara Guilcher, Gregory M.T. Hashmi, Javeria Heathcote, Lauren C. Noel, Melanie Schulte, Fiona S.M. Stinson, Jennifer N. Stern, Maya |
author_sort | Tutelman, Perri R. |
collection | PubMed |
description | Cancer and its treatment can have lasting consequences on somatosensation, including pain, which is often underrecognized and undertreated. Research characterizing the impact of cancer on pain and sensory processing in survivors of childhood cancer is scarce. This study aimed to quantify generalized differences in pain and sensory processing in survivors of childhood cancer compared with reference data using a standardized thermal and mechanical quantitative sensory testing (QST) protocol. The association between demographic, clinical (eg, leukemia vs other cancers and treatment exposures), and psychosocial (eg, anxiety and pain catastrophizing) variables and sensitivity to pain and sensory stimuli were also evaluated. Participants were 56 survivors of various types of childhood cancer (52% male, M(age) = 13.5 years, SD = 3.2, range = 8-17 years). On average, children were 7 years (SD = 4.1, range = 1.2-16.5) post treatment. Almost all participants (86%) had at least 1 abnormal QST parameter compared with age- and sex-matched reference data; however, few participants self-reported the presence of sensory abnormalities. Generally, participants exhibited reduced sensitivity across the QST parameters examined (Ps < 0.05, ds = 0.40-3.45). A significant minority (45%) also exhibited pain sensitization (P <0.001, d = 0.42). Several risk factors for changes in sensory processing were identified, including current age, history of leukemia, certain treatment exposures (eg, vincristine cumulative dose, major surgery, and bone marrow or stem cell transplant), time off treatment, and higher anxiety and pain catastrophizing scores. Overall, this study demonstrated that somatosensory changes are prevalent in survivors of childhood cancer years after the completion of treatment. Future research is needed to understand long-term implications of altered somatosensation in this complex population. |
format | Online Article Text |
id | pubmed-9100454 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Wolters Kluwer |
record_format | MEDLINE/PubMed |
spelling | pubmed-91004542022-05-16 Long-term alterations in somatosensory functioning in survivors of childhood cancer Tutelman, Perri R. Chambers, Christine T. Cornelissen, Laura Fernandez, Conrad V. Flanders, Annette MacLeod, Julia Sherry, Simon B. Stewart, Sherry H. Urquhart, Robin de Gagne, Sitara Guilcher, Gregory M.T. Hashmi, Javeria Heathcote, Lauren C. Noel, Melanie Schulte, Fiona S.M. Stinson, Jennifer N. Stern, Maya Pain Research Paper Cancer and its treatment can have lasting consequences on somatosensation, including pain, which is often underrecognized and undertreated. Research characterizing the impact of cancer on pain and sensory processing in survivors of childhood cancer is scarce. This study aimed to quantify generalized differences in pain and sensory processing in survivors of childhood cancer compared with reference data using a standardized thermal and mechanical quantitative sensory testing (QST) protocol. The association between demographic, clinical (eg, leukemia vs other cancers and treatment exposures), and psychosocial (eg, anxiety and pain catastrophizing) variables and sensitivity to pain and sensory stimuli were also evaluated. Participants were 56 survivors of various types of childhood cancer (52% male, M(age) = 13.5 years, SD = 3.2, range = 8-17 years). On average, children were 7 years (SD = 4.1, range = 1.2-16.5) post treatment. Almost all participants (86%) had at least 1 abnormal QST parameter compared with age- and sex-matched reference data; however, few participants self-reported the presence of sensory abnormalities. Generally, participants exhibited reduced sensitivity across the QST parameters examined (Ps < 0.05, ds = 0.40-3.45). A significant minority (45%) also exhibited pain sensitization (P <0.001, d = 0.42). Several risk factors for changes in sensory processing were identified, including current age, history of leukemia, certain treatment exposures (eg, vincristine cumulative dose, major surgery, and bone marrow or stem cell transplant), time off treatment, and higher anxiety and pain catastrophizing scores. Overall, this study demonstrated that somatosensory changes are prevalent in survivors of childhood cancer years after the completion of treatment. Future research is needed to understand long-term implications of altered somatosensation in this complex population. Wolters Kluwer 2022-06 2021-09-25 /pmc/articles/PMC9100454/ /pubmed/34855647 http://dx.doi.org/10.1097/j.pain.0000000000002486 Text en Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the International Association for the Study of Pain. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
spellingShingle | Research Paper Tutelman, Perri R. Chambers, Christine T. Cornelissen, Laura Fernandez, Conrad V. Flanders, Annette MacLeod, Julia Sherry, Simon B. Stewart, Sherry H. Urquhart, Robin de Gagne, Sitara Guilcher, Gregory M.T. Hashmi, Javeria Heathcote, Lauren C. Noel, Melanie Schulte, Fiona S.M. Stinson, Jennifer N. Stern, Maya Long-term alterations in somatosensory functioning in survivors of childhood cancer |
title | Long-term alterations in somatosensory functioning in survivors of childhood cancer |
title_full | Long-term alterations in somatosensory functioning in survivors of childhood cancer |
title_fullStr | Long-term alterations in somatosensory functioning in survivors of childhood cancer |
title_full_unstemmed | Long-term alterations in somatosensory functioning in survivors of childhood cancer |
title_short | Long-term alterations in somatosensory functioning in survivors of childhood cancer |
title_sort | long-term alterations in somatosensory functioning in survivors of childhood cancer |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9100454/ https://www.ncbi.nlm.nih.gov/pubmed/34855647 http://dx.doi.org/10.1097/j.pain.0000000000002486 |
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