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Atherosclerosis and Cardiovascular Diseases in Progeroid Syndromes
Hutchinson–Gilford progeria syndrome (HGPS) and Werner syndrome (WS) are two of the representative genetic progeroid syndromes and have been widely studied in the field of aging research. HGPS is a pediatric disease in which premature aging symptoms appear in early childhood, and death occurs at an...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Japan Atherosclerosis Society
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9100459/ https://www.ncbi.nlm.nih.gov/pubmed/34511576 http://dx.doi.org/10.5551/jat.RV17061 |
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author | Kato, Hisaya Maezawa, Yoshiro |
author_facet | Kato, Hisaya Maezawa, Yoshiro |
author_sort | Kato, Hisaya |
collection | PubMed |
description | Hutchinson–Gilford progeria syndrome (HGPS) and Werner syndrome (WS) are two of the representative genetic progeroid syndromes and have been widely studied in the field of aging research. HGPS is a pediatric disease in which premature aging symptoms appear in early childhood, and death occurs at an average age of 14.5 years, mainly due to cardiovascular disease (CVD). Conversely, WS patients exhibit accelerated aging phenotypes after puberty and die in their 50s due to CVD and malignant tumors. Both diseases are models of human aging, leading to a better understanding of the aging-associated development of CVD. In this review, we discuss the pathogenesis and treatment of atherosclerotic diseases presented by both progeroid syndromes with the latest findings. |
format | Online Article Text |
id | pubmed-9100459 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Japan Atherosclerosis Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-91004592022-05-26 Atherosclerosis and Cardiovascular Diseases in Progeroid Syndromes Kato, Hisaya Maezawa, Yoshiro J Atheroscler Thromb Review Hutchinson–Gilford progeria syndrome (HGPS) and Werner syndrome (WS) are two of the representative genetic progeroid syndromes and have been widely studied in the field of aging research. HGPS is a pediatric disease in which premature aging symptoms appear in early childhood, and death occurs at an average age of 14.5 years, mainly due to cardiovascular disease (CVD). Conversely, WS patients exhibit accelerated aging phenotypes after puberty and die in their 50s due to CVD and malignant tumors. Both diseases are models of human aging, leading to a better understanding of the aging-associated development of CVD. In this review, we discuss the pathogenesis and treatment of atherosclerotic diseases presented by both progeroid syndromes with the latest findings. Japan Atherosclerosis Society 2022-04-01 2021-09-11 /pmc/articles/PMC9100459/ /pubmed/34511576 http://dx.doi.org/10.5551/jat.RV17061 Text en 2022 Japan Atherosclerosis Society https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.http://creativecommons.org/licenses/by-nc-sa/4.0/ (https://creativecommons.org/licenses/by-nc-sa/4.0/) |
spellingShingle | Review Kato, Hisaya Maezawa, Yoshiro Atherosclerosis and Cardiovascular Diseases in Progeroid Syndromes |
title | Atherosclerosis and Cardiovascular Diseases in Progeroid Syndromes |
title_full | Atherosclerosis and Cardiovascular Diseases in Progeroid Syndromes |
title_fullStr | Atherosclerosis and Cardiovascular Diseases in Progeroid Syndromes |
title_full_unstemmed | Atherosclerosis and Cardiovascular Diseases in Progeroid Syndromes |
title_short | Atherosclerosis and Cardiovascular Diseases in Progeroid Syndromes |
title_sort | atherosclerosis and cardiovascular diseases in progeroid syndromes |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9100459/ https://www.ncbi.nlm.nih.gov/pubmed/34511576 http://dx.doi.org/10.5551/jat.RV17061 |
work_keys_str_mv | AT katohisaya atherosclerosisandcardiovasculardiseasesinprogeroidsyndromes AT maezawayoshiro atherosclerosisandcardiovasculardiseasesinprogeroidsyndromes |