Cargando…

Targeting Mitochondrial Oxidative Phosphorylation Eradicates Acute Myeloid Leukemic Stem Cells

Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy characterized by multiple cytogenetic and molecular abnormalities, with a very poor prognosis. Current treatments for AML often fail to eliminate leukemic stem cells (LSCs), which perpetuate the disease. LSCs exhibit a unique met...

Descripción completa

Detalles Bibliográficos
Autores principales:	Peng, Meixi, Huang, Yongxiu, Zhang, Ling, Zhao, Xueya, Hou, Yu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9100571/ https://www.ncbi.nlm.nih.gov/pubmed/35574326 http://dx.doi.org/10.3389/fonc.2022.899502

Ejemplares similares

Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemic stem cells
por: Kuntz, Elodie M., et al.
Publicado: (2017)

Harnessing the Metabolic Vulnerabilities of Leukemia Stem Cells to Eradicate Acute Myeloid Leukemia
por: Kumar, Bijender
Publicado: (2021)

Escape From Treatment; the Different Faces of Leukemic Stem Cells and Therapy Resistance in Acute Myeloid Leukemia
por: van Gils, Noortje, et al.
Publicado: (2021)

Characteristics of leukemic stem cells in acute leukemia and potential targeted therapies for their specific eradication
por: Hansen, Quinty, et al.
Publicado: (2022)

Extramedullary Acute Myeloid Leukemia: Leukemic Pleural Effusion, Case Report and Review of the Literature
por: Pemmaraju, Naveen, et al.
Publicado: (2014)

Can immunotherapy specifically target acute myeloid leukemic stem cells?
por: Snauwaert, Sylvia, et al.
Publicado: (2013)

The Polycomb BMI1 Protein Is Co-expressed With CD26+ in Leukemic Stem Cells of Chronic Myeloid Leukemia
por: Galimberti, Sara, et al.
Publicado: (2018)

Targeted activation of GPER enhances the efficacy of venetoclax by boosting leukemic pyroptosis and CD8+ T cell immune function in acute myeloid leukemia
por: Ren, Jun, et al.
Publicado: (2022)

Deciphering Metabolic Adaptability of Leukemic Stem Cells
por: Patel, Sweta B., et al.
Publicado: (2022)

Leukemic stem cell signatures identify novel therapeutics targeting acute myeloid leukemia
por: Laverdière, Isabelle, et al.
Publicado: (2018)

TARP is an immunotherapeutic target in acute myeloid leukemia expressed in the leukemic stem cell compartment
por: Depreter, Barbara, et al.
Publicado: (2020)

Leukemic stem cells and therapy resistance in acute myeloid leukemia
por: Stelmach, Patrick, et al.
Publicado: (2023)

Inflammatory Signaling Pathways in Preleukemic and Leukemic Stem Cells
por: Hemmati, Shayda, et al.
Publicado: (2017)

Therapeutic targeting of leukemia stem cells in acute myeloid leukemia
por: Barbosa, Karina, et al.
Publicado: (2023)

Oxidative Phosphorylation Fueled by Fatty Acid Oxidation Sensitizes Leukemic Stem Cells to Cold
por: Griessinger, Emmanuel, et al.
Publicado: (2023)

The Histone Deacetylase Inhibitor I13 Induces Differentiation of M2, M3 and M5 Subtypes of Acute Myeloid Leukemia Cells and Leukemic Stem-Like Cells
por: Ma, Xiangyu, et al.
Publicado: (2022)

The role of mitochondrial proteases in leukemic cells and leukemic stem cells
por: Mirali, Sara, et al.
Publicado: (2020)

Mutant NPM1-Regulated FTO-Mediated m(6)A Demethylation Promotes Leukemic Cell Survival via PDGFRB/ERK Signaling Axis
por: Xiao, Qiaoling, et al.
Publicado: (2022)

Leukemic Stem Cell: A Mini-Review on Clinical Perspectives
por: Barreto, Igor Valentim, et al.
Publicado: (2022)

CD9 in acute myeloid leukemia: Prognostic role and usefulness to target leukemic stem cells
por: Touzet, Lucas, et al.
Publicado: (2019)

Targeting Leukemic Stem Cells in Chronic Myeloid Leukemia: Is It Worth the Effort?
por: Soverini, Simona, et al.
Publicado: (2021)

Residual Peripheral Blood CD26(+) Leukemic Stem Cells in Chronic Myeloid Leukemia Patients During TKI Therapy and During Treatment-Free Remission
por: Bocchia, Monica, et al.
Publicado: (2018)

Drug Resistance Mechanisms of Acute Myeloid Leukemia Stem Cells
por: Niu, Jialan, et al.
Publicado: (2022)

Targeting AXL kinase sensitizes leukemic stem and progenitor cells to venetoclax treatment in acute myeloid leukemia
por: Niu, Xiaojia, et al.
Publicado: (2021)

One Disease, Multiple Hits: Acute Myeloid Leukemia With t(10;11) Presenting With Leukemic Lung Infiltration as First Presentation and Facial Nerve Palsy at Relapse
por: AL-Busaidi, Thuraya, et al.
Publicado: (2023)

Leukemic stem cell phenotype is associated with mutational profile in acute myeloid leukemia
por: Han, Heejoo, et al.
Publicado: (2021)

Targeting oxidative phosphorylation as an approach for the treatment of ovarian cancer
por: Wu, Yinjie, et al.
Publicado: (2022)

Toward Therapeutic Targeting of Bone Marrow Leukemic Niche Protective Signals in B-Cell Acute Lymphoblastic Leukemia
por: Delahaye, Marjorie C., et al.
Publicado: (2021)

Targeting Lactate Metabolism by Inhibiting MCT1 or MCT4 Impairs Leukemic Cell Proliferation, Induces Two Different Related Death-Pathways and Increases Chemotherapeutic Sensitivity of Acute Myeloid Leukemia Cells
por: Saulle, Ernestina, et al.
Publicado: (2021)

Antiproliferative Effects of the Natural Oxadiazine Nocuolin A Are Associated With Impairment of Mitochondrial Oxidative Phosphorylation
por: Sousa, Maria Lígia, et al.
Publicado: (2019)

Biochanin A Inhibits Glioblastoma Growth via Restricting Glycolysis and Mitochondrial Oxidative Phosphorylation
por: Dong, Qiang, et al.
Publicado: (2021)

Circulating plasma exosomal long non-coding RNAs LINC00265, LINC00467, UCA1, and SNHG1 as biomarkers for diagnosis and treatment monitoring of acute myeloid leukemia
por: Xiao, Qiaoling, et al.
Publicado: (2022)

Properties of Leukemic Stem Cells in Regulating Drug Resistance in Acute and Chronic Myeloid Leukemias
por: Zhai, Xingjian, et al.
Publicado: (2022)

Corrigendum: Antiproliferative effects of the natural oxadiazine Nocuolin A are associated with impairment of mitochondrial oxidative phosphorylation
por: Sousa, Maria Lígia, et al.
Publicado: (2023)

P421: TARGETED DISRUPTION OF HUMAN FLT3 ERADICATES LEUKEMIC STEM CELLS WITHOUT HARMING HEALTHY HEMATOPOIETIC STEM CELLS
por: Araújo, Joana, et al.
Publicado: (2023)

Targeting the Leukemic stem cell protein machinery by inhibition of mitochondrial pyrimidine synthesis
por: Donato, Elisa, et al.
Publicado: (2022)

Targeting ERRα promotes cytotoxic effects against acute myeloid leukemia through suppressing mitochondrial oxidative phosphorylation
por: Seo, Wonhyoung, et al.
Publicado: (2022)

Preleukemic Hematopoietic Stem Cells in Human Acute Myeloid Leukemia
por: Corces, M. Ryan, et al.
Publicado: (2017)

P465: N-MYRISTOYLATION INHIBITION ABROGATES OXIDATIVE PHOSPHORYLATION TO TARGET ACUTE MYELOID LEUKEMIA STEM CELLS
por: Gamma, Jay, et al.
Publicado: (2023)

Targeting Bcl-2 Proteins in Acute Myeloid Leukemia
por: Wei, Yunxiong, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_g2irn8d5mfprk8fbe1h9af4q5k