DAPT Attenuates Cadmium-Induced Toxicity in Mice by Inhibiting Inflammation and the Notch/HES-1 Signaling Axis

The small molecule DAPT inhibits the Notch signaling pathway by blocking γ-secretase mediated Notch cleavage. Given the critical role of the Notch signaling axis in inflammation, we asked whether DAPT could block Notch-mediated inflammation and thus exert neuronal protection. We established a mouse...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Jia-Ying, Shen, Dan-Yang, Wang, Jun, Dai, Jing-Feng, Qin, Xiao-Yan, Hu, Yang, Lan, Rongfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9100577/
https://www.ncbi.nlm.nih.gov/pubmed/35571137
http://dx.doi.org/10.3389/fphar.2022.902796

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9100577/
https://www.ncbi.nlm.nih.gov/pubmed/35571137
http://dx.doi.org/10.3389/fphar.2022.902796

Ejemplares similares