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DAPT Attenuates Cadmium-Induced Toxicity in Mice by Inhibiting Inflammation and the Notch/HES-1 Signaling Axis

The small molecule DAPT inhibits the Notch signaling pathway by blocking γ-secretase mediated Notch cleavage. Given the critical role of the Notch signaling axis in inflammation, we asked whether DAPT could block Notch-mediated inflammation and thus exert neuronal protection. We established a mouse...

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Detalles Bibliográficos
Autores principales:	Yang, Jia-Ying, Shen, Dan-Yang, Wang, Jun, Dai, Jing-Feng, Qin, Xiao-Yan, Hu, Yang, Lan, Rongfeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9100577/ https://www.ncbi.nlm.nih.gov/pubmed/35571137 http://dx.doi.org/10.3389/fphar.2022.902796

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