Upregulation of the Mevalonate Pathway through EWSR1-FLI1/EGR2 Regulatory Axis Confers Ewing Cells Exquisite Sensitivity to Statins

SIMPLE SUMMARY: The objective of this project was to search for new dependencies in Ewing sarcoma, a deadly disease for which new therapeutic approaches are urgently needed. A pharmacological screening of off-patent approved drugs (FDA agency) and the investigation of downstream targets of EGR2 were...

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Detalles Bibliográficos
Autores principales: Buchou, Charlie, Laud-Duval, Karine, van der Ent, Wietske, Grossetête, Sandrine, Zaidi, Sakina, Gentric, Géraldine, Corbé, Maxime, Müller, Kévin, Del Nery, Elaine, Surdez, Didier, Delattre, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9100622/
https://www.ncbi.nlm.nih.gov/pubmed/35565457
http://dx.doi.org/10.3390/cancers14092327

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